Sensitivity and specificity of the ganglion cell analysis for cirrus HD-OCT using data from PROGRESSA study

Jude Fitzgerald, Bronwyn Usher, John Landers, Robert Casson, Anna Galanopoulos, Stuart Graham, Ashish Agar, Paul Healey, Jamie Craig

    Research output: Contribution to journalMeeting abstract


    Purpose: The aim of this study was to evaluate the use of ganglion cell analysis on Cirrus HD-OCT in diagnosis of perimetric glaucoma Method: We studied 1038 patients classified as either glaucoma suspects or early manifest (perimetric) glaucoma. Ganglion cell analysis data were available for analysis in 780 patients. Ganglion cell analysis thickness for manifest (perimetric) glaucoma patients was compared to that with pre-perimetric glaucoma and glaucoma suspects. The sensitivity and specificity of the normative database to diagnose glaucoma were calculated. Results: We analysed 383 eyes with early glaucoma and 960 glaucoma suspect eyes. There was a statistically significant (P < 0.0001) difference in ganglion cell thickness in all six sectors and in average and minimum thickness between the suspect and early glaucoma populations. The greatest difference was seen in the infero-temporal sector. The normative database has a sensitivity of 81.3% and specificity of 62.0% when differentiating early perimetric glaucoma from glaucoma suspects using the ganglion cell analysis. Conclusion: A statistically significant difference is seen in the thickness of the ganglion cell layer when comparing a glaucoma suspect population to an early glaucoma population. The normative database is more sensitive than specific to differentiate early glaucoma from suspects. The poor specificity could be due to the glaucoma suspect population including those who have preperimetric glaucoma and the ganglion cell analysis identifying glaucomatous change earlier than perimetry.
    Original languageEnglish
    Article number48
    Pages (from-to)96
    Number of pages1
    JournalClinical and Experimental Ophthalmology
    Issue numberS1
    Publication statusPublished - Oct 2015
    EventAnnual Scientific Congress of the Royal Australian and New Zealand College of Ophthalmologists (47th : 2015) - Wellington, New Zealand
    Duration: 31 Oct 20154 Nov 2015

    Cite this