Sensors and Instrumentation towards early detection of osteoporosis

Nasrin Afsarimanesh, Subhas C. Mukhopadhyay, Marlena Kruger, Pak Lam Yu, Jurgen Kosel

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

3 Citations (Scopus)

Abstract

A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems.

Original languageEnglish
Title of host publication2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings
Subtitle of host publicationMeasuring the Pulse of Industries, Nature and Humans
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1-6
Number of pages6
ISBN (Electronic)9781467392204
DOIs
Publication statusPublished - 22 Jul 2016
Externally publishedYes
Event2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016 - Taipei, Taiwan, Province of China
Duration: 23 May 201626 May 2016

Other

Other2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016
CountryTaiwan, Province of China
CityTaipei
Period23/05/1626/05/16

Keywords

  • Complex Non-linear Least Square (CNLS)
  • Electrochemical Impedance Spectroscopy(EIS)
  • ELISA
  • interdigital sensor
  • Osteoporosis

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