Sensors and Instrumentation towards early detection of osteoporosis

Nasrin Afsarimanesh; Subhas C. Mukhopadhyay; Marlena Kruger; Pak Lam Yu; Jurgen Kosel

doi:10.1109/I2MTC.2016.7520573

Sensors and Instrumentation towards early detection of osteoporosis

Nasrin Afsarimanesh, Subhas C. Mukhopadhyay, Marlena Kruger, Pak Lam Yu, Jurgen Kosel

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

3 Citations (Scopus)

Abstract

A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems.

Original language	English
Title of host publication	2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings
Subtitle of host publication	Measuring the Pulse of Industries, Nature and Humans
Place of Publication	Piscataway, NJ
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	1-6
Number of pages	6
ISBN (Electronic)	9781467392204
DOIs	https://doi.org/10.1109/I2MTC.2016.7520573
Publication status	Published - 22 Jul 2016
Externally published	Yes
Event	2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016 - Taipei, Taiwan Duration: 23 May 2016 → 26 May 2016

Other

Other	2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016
Country/Territory	Taiwan
City	Taipei
Period	23/05/16 → 26/05/16

Keywords

Complex Non-linear Least Square (CNLS)
Electrochemical Impedance Spectroscopy(EIS)
ELISA
interdigital sensor
Osteoporosis

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10.1109/I2MTC.2016.7520573

Cite this

Afsarimanesh, N., Mukhopadhyay, S. C., Kruger, M., Yu, P. L., & Kosel, J. (2016). Sensors and Instrumentation towards early detection of osteoporosis. In 2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings: Measuring the Pulse of Industries, Nature and Humans (pp. 1-6). [7520573] Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/I2MTC.2016.7520573

Afsarimanesh, Nasrin ; Mukhopadhyay, Subhas C. ; Kruger, Marlena et al. / Sensors and Instrumentation towards early detection of osteoporosis. 2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings: Measuring the Pulse of Industries, Nature and Humans. Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE), 2016. pp. 1-6

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abstract = "A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems.",

keywords = "Complex Non-linear Least Square (CNLS), Electrochemical Impedance Spectroscopy(EIS), ELISA, interdigital sensor, Osteoporosis",

author = "Nasrin Afsarimanesh and Mukhopadhyay, {Subhas C.} and Marlena Kruger and Yu, {Pak Lam} and Jurgen Kosel",

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doi = "10.1109/I2MTC.2016.7520573",

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booktitle = "2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings",

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Afsarimanesh, N, Mukhopadhyay, SC, Kruger, M, Yu, PL & Kosel, J 2016, Sensors and Instrumentation towards early detection of osteoporosis. in 2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings: Measuring the Pulse of Industries, Nature and Humans., 7520573, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, pp. 1-6, 2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016, Taipei, Taiwan, 23/05/16. https://doi.org/10.1109/I2MTC.2016.7520573

Sensors and Instrumentation towards early detection of osteoporosis. / Afsarimanesh, Nasrin; Mukhopadhyay, Subhas C.; Kruger, Marlena et al.

2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings: Measuring the Pulse of Industries, Nature and Humans. Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE), 2016. p. 1-6 7520573.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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Afsarimanesh N, Mukhopadhyay SC, Kruger M, Yu PL, Kosel J. Sensors and Instrumentation towards early detection of osteoporosis. In 2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings: Measuring the Pulse of Industries, Nature and Humans. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE). 2016. p. 1-6. 7520573 https://doi.org/10.1109/I2MTC.2016.7520573

Sensors and Instrumentation towards early detection of osteoporosis

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