Abstract
A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems.
Original language | English |
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Title of host publication | 2016 IEEE International Instrumentation and Measurement Technology Conference (I²MTC) Proceedings |
Subtitle of host publication | Measuring the Pulse of Industries, Nature and Humans |
Place of Publication | Piscataway, NJ |
Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
Pages | 1-6 |
Number of pages | 6 |
ISBN (Electronic) | 9781467392204 |
DOIs | |
Publication status | Published - 22 Jul 2016 |
Externally published | Yes |
Event | 2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016 - Taipei, Taiwan Duration: 23 May 2016 → 26 May 2016 |
Other
Other | 2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016 |
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Country/Territory | Taiwan |
City | Taipei |
Period | 23/05/16 → 26/05/16 |
Keywords
- Complex Non-linear Least Square (CNLS)
- Electrochemical Impedance Spectroscopy(EIS)
- ELISA
- interdigital sensor
- Osteoporosis