Sequence of the ebgA gene of Escherichia coli

comparison with the lacZ gene

H. W. Stokes, P. W. Betts, B. G. Hall

Research output: Contribution to journalArticle

35 Citations (Scopus)


We have sequenced the ebgA (evolved β-galactosidase) gene of Escherichia coli K12. The sequence shows 50% nucleotide identity with the E. coli lacZ gene, demonstrating that the two genes are related by descent from a common ancestral gene. Comparison of the two sequences suggests that the ebgA gene has recently been under selection. A significant excess of identical, rather than synonymous, codons used to encode identical amino acids at the same positions in the aligned sequences implies that some form of selection is operating directly at the DNA level. This selection is independent of, and in addition to, selection based on codon usage or on function of the gene products.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalMolecular Biology and Evolution
Issue number6
Publication statusPublished - 1985

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