Inhibition par la sérotonine de l'infection par VIH-1 des macrophages en culture primaire: rôle du sous-type 5-HT1A des récepteurs sérotoninergiques

Translated title of the contribution: Serotonin modulates HIV replication in primary culture of human macrophages: involvement of 5-HT1A sub-type receptors

B. Manéglier*, O. Spreux-Varoquaux, G. J. Guillemin, C. Rogez-Kreuz, D. Dormont, C. Advenier, P. Clayette

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The neurotransmitter 5-hydroxytryptamine (5-HT), commonly known as serotonin, is released at peripheral sites from activated platelets. At inflammatory sites, macrophages and lymphocytes could be exposed to 5-HT concentrations up to 100 μM. Moreover, 5-HT could modulate cytokine secretion by monocytes/macrophages and immune functions through the uptake of 5-HT at these inflammatory sites from T cells and dendritic cells. HIV infection is also under the control of inflammatory processes (including T cell proliferation and cytokines secretion). On this basis, we studied explored herein the effects of 5-HT on HIV-1/Ba-L (macrophage-tropic virus) replication in primary cultures of human macrophages. This pharmacological study with isotype-selective receptor agonists and antagonist allowed us to show that the 100 μM 5-HT concentration via 5-HT1A subtype receptors could decrease HIV replication. This observation was associated with an increase of MIP-1α secretion such as an increase of MIP-1α mRNA production and with a decrease of HIV-coreceptor CCR5 cell surface expression. Our results point out for the first time the inhibitory effects of 5-HT on HIV replication in primary culture of human macrophages via activation of 5-HT1A subtype receptors.

Translated title of the contributionSerotonin modulates HIV replication in primary culture of human macrophages: involvement of 5-HT1A sub-type receptors
Original languageFrench
Pages (from-to)495-503
Number of pages9
JournalPathologie Biologie
Volume55
Issue number10
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

Keywords

  • CCR5
  • HIV-1
  • Macrophages
  • MIP-1α
  • Serotonin

Fingerprint Dive into the research topics of 'Serotonin modulates HIV replication in primary culture of human macrophages: involvement of 5-HT1A sub-type receptors'. Together they form a unique fingerprint.

Cite this