SERS Nanotags

Nana Lyu, Yuling Wang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

SERS is a vibrational spectral technique, which is widely used in bioanalytical chemistry and life sciences. SERS nanotag as an alternative label for both immunoassay and microscopic bioimaging has experienced tremendous progress in the past few years with unique advantages and applications that are not achievable with organic dyes or molecular fluorophores. The advantages of SERS nanotags include the quantification, sensitivity, photostability, and spectral multiplexing for simultaneous target detection. Significant advances in the rational design and synthesis of bright plasmonic NPs as the core of SERS nanotags have been accomplished, including control over size/shape and nanoassemblies with multiple hot spots. Moreover, the diversity of molecules (from the dye molecules to small molecules) provides a flexible choice of Raman reporters depending on the applications. Along with the development of the protective layers (e.g., polymer/ biopolymer, silica) as well as the spacer/linker molecules, SERS nanotags are expected to find more applications in biomedical and clinical applications. However, the design and synthesis of stable and well-defined 3D plasmonic nanoassemblies with multiple hot spots for very high sensitivity remain as challenging as ever. For reproducibility and quantification, the use of purified colloids with a well-defined composition (no mixtures), as well the design and synthesis of Raman reporters with similar Raman crosssections, is very important for multiplex detection. Furthermore, the stability and storage of SERS nanotags are the other key issues that need to be considered in the future for the reliable application.

Original languageEnglish
Title of host publicationWorld Scientific Reference on Plasmonic Nanomaterials
Subtitle of host publicationPrinciples, Design and Bio-applications: Volume 5: Plasmonics in Diagnostics and Therapy
EditorsSebastian Schlücker
Place of PublicationSingapore
PublisherWorld Scientific Publishing
Chapter6
Pages215-243
Number of pages29
ISBN (Electronic)9789811235252
ISBN (Print)9789811235207
DOIs
Publication statusPublished - 2022

Publication series

NameWorld Scientific Series in Nanoscience and Nanotechnology
Number5
Volume22
ISSN (Print)2301-301X
ISSN (Electronic)2335-6693

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