Serum biomarkers of neurologic injury in cardiac operations

Michael Seco; J. James B. Edelman; Michael K. Wilson; Paul G. Bannon; Michael P. Vallely

doi:10.1016/j.athoracsur.2012.04.142

Serum biomarkers of neurologic injury in cardiac operations

Michael Seco, J. James B. Edelman, Michael K. Wilson, Paul G. Bannon, Michael P. Vallely^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.

Original language	English
Pages (from-to)	1026-1033
Number of pages	8
Journal	Annals of Thoracic Surgery
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/j.athoracsur.2012.04.142
Publication status	Published - Sept 2012
Externally published	Yes

Keywords

Biomarkers/blood
Cardiac Surgical Procedures/adverse effects
Cognition Disorders/blood
Female
Glial Fibrillary Acidic Protein/blood
Humans
Male
Nerve Growth Factors/blood
Nervous System Diseases/blood
Phosphopyruvate Hydratase/blood
Postoperative Complications/blood
Prognosis
S100 Proteins/blood
Sensitivity and Specificity

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10.1016/j.athoracsur.2012.04.142

Cite this

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title = "Serum biomarkers of neurologic injury in cardiac operations",

abstract = "Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.",

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author = "Michael Seco and Edelman, {J. James B.} and Wilson, {Michael K.} and Bannon, {Paul G.} and Vallely, {Michael P.}",

year = "2012",

month = sep,

doi = "10.1016/j.athoracsur.2012.04.142",

language = "English",

volume = "94",

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journal = "Annals of Thoracic Surgery",

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TY - JOUR

T1 - Serum biomarkers of neurologic injury in cardiac operations

AU - Seco, Michael

AU - Edelman, J. James B.

AU - Wilson, Michael K.

AU - Bannon, Paul G.

AU - Vallely, Michael P.

PY - 2012/9

Y1 - 2012/9

N2 - Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.

AB - Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.

KW - Biomarkers/blood

KW - Cardiac Surgical Procedures/adverse effects

KW - Cognition Disorders/blood

KW - Female

KW - Glial Fibrillary Acidic Protein/blood

KW - Humans

KW - Male

KW - Nerve Growth Factors/blood

KW - Nervous System Diseases/blood

KW - Phosphopyruvate Hydratase/blood

KW - Postoperative Complications/blood

KW - Prognosis

KW - S100 Proteins/blood

KW - Sensitivity and Specificity

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DO - 10.1016/j.athoracsur.2012.04.142

M3 - Review article

C2 - 22857981

AN - SCOPUS:84865276625

SN - 0003-4975

VL - 94

SP - 1026

EP - 1033

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 3

ER -

Serum biomarkers of neurologic injury in cardiac operations

Abstract

Keywords

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