Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss

Bamini Gopinath, Victoria M. Flood, Elena Rochtchina, Catherine M. McMahon, Paul Mitchell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Elevated total serum homocysteine (tHcy) concentrations associated with vitamin B-12 or folate deficiencies may adversely affect blood flow to the cochlea, leading to age-related hearing loss (presbycusis). However, only 2 small crosssectional studies have assessed the link between folate, vitamin B-12, or tHcy and presbycusis. We aimed to determine both the cross-sectional and longitudinal association between serum concentrations of folate, vitamin B-12, or tHcy and risk of age-related hearing loss. The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997-1999 to 2002-2004). Presbycusis was measured in 2956 participants (aged ≥50 y) and was defined as the puretone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB hearing level (HL). Serum concentrations of folate, vitamin B-12, and tHcy were determined from blood samples. Participants with elevated tHcy (>20 μmol/L) concentrations had a 64% increased likelihood of prevalent hearing loss (>25 dB HL) [multivariate-adjusted odds ratio (OR) 1.64; 95% CI, 1.06-2.53]. Low serum folate levels (<11 nmol/L) increased the odds of prevalent mild hearing loss (>25-40 dB HL), multivariate-adjusted [OR 1.37 (CI 1.04-1.81)]. Serum vitamin B-12, however, was not significantly associated with prevalent hearing loss. Serum folate, vitamin B-12, and tHcy concentrations were also not significantly associated with an increased risk of incident hearing loss. Serum concentrations of tHcy and folate were associated with age-related hearing loss cross-sectionally, but no temporal links were observed, which could be due to insufficient study power. Further, large prospective studies will be required in the future to assess these associations.

LanguageEnglish
Pages1469-1474
Number of pages6
JournalJournal of Nutrition
Volume140
Issue number8
DOIs
Publication statusPublished - Aug 2010

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Homocysteine
Hearing Loss
Folic Acid
Serum
Vitamin B 12
Presbycusis
Hearing
Odds Ratio
Cochlea
Prospective Studies

Cite this

Gopinath, Bamini ; Flood, Victoria M. ; Rochtchina, Elena ; McMahon, Catherine M. ; Mitchell, Paul. / Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. In: Journal of Nutrition. 2010 ; Vol. 140, No. 8. pp. 1469-1474.
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abstract = "Elevated total serum homocysteine (tHcy) concentrations associated with vitamin B-12 or folate deficiencies may adversely affect blood flow to the cochlea, leading to age-related hearing loss (presbycusis). However, only 2 small crosssectional studies have assessed the link between folate, vitamin B-12, or tHcy and presbycusis. We aimed to determine both the cross-sectional and longitudinal association between serum concentrations of folate, vitamin B-12, or tHcy and risk of age-related hearing loss. The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997-1999 to 2002-2004). Presbycusis was measured in 2956 participants (aged ≥50 y) and was defined as the puretone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB hearing level (HL). Serum concentrations of folate, vitamin B-12, and tHcy were determined from blood samples. Participants with elevated tHcy (>20 μmol/L) concentrations had a 64{\%} increased likelihood of prevalent hearing loss (>25 dB HL) [multivariate-adjusted odds ratio (OR) 1.64; 95{\%} CI, 1.06-2.53]. Low serum folate levels (<11 nmol/L) increased the odds of prevalent mild hearing loss (>25-40 dB HL), multivariate-adjusted [OR 1.37 (CI 1.04-1.81)]. Serum vitamin B-12, however, was not significantly associated with prevalent hearing loss. Serum folate, vitamin B-12, and tHcy concentrations were also not significantly associated with an increased risk of incident hearing loss. Serum concentrations of tHcy and folate were associated with age-related hearing loss cross-sectionally, but no temporal links were observed, which could be due to insufficient study power. Further, large prospective studies will be required in the future to assess these associations.",
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Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. / Gopinath, Bamini; Flood, Victoria M.; Rochtchina, Elena; McMahon, Catherine M.; Mitchell, Paul.

In: Journal of Nutrition, Vol. 140, No. 8, 08.2010, p. 1469-1474.

Research output: Contribution to journalArticleResearchpeer-review

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