Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

Steven E. Oliver*, Barney Barrass, David J. Gunnell, Jenny L. Donovan, Tim J. Peters, Raj A. Persad, David Gillatt, David E. Neal, Freddie C. Hamdy, Jeff M.P. Holly

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2004
Externally publishedYes

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