Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

Steven E. Oliver; Barney Barrass; David J. Gunnell; Jenny L. Donovan; Tim J. Peters; Raj A. Persad; David Gillatt; David E. Neal; Freddie C. Hamdy; Jeff M.P. Holly

doi:10.1158/1055-9965.EPI-03-0102

Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

Steven E. Oliver^*, Barney Barrass, David J. Gunnell, Jenny L. Donovan, Tim J. Peters, Raj A. Persad, David Gillatt, David E. Neal, Freddie C. Hamdy, Jeff M.P. Holly

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

Original language	English
Pages (from-to)	163-165
Number of pages	3
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	13
Issue number	1
DOIs	https://doi.org/10.1158/1055-9965.EPI-03-0102
Publication status	Published - Jan 2004
Externally published	Yes

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Oliver, S. E., Barrass, B., Gunnell, D. J., Donovan, J. L., Peters, T. J., Persad, R. A., Gillatt, D., Neal, D. E., Hamdy, F. C., & Holly, J. M. P. (2004). Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer. Cancer Epidemiology Biomarkers and Prevention, 13(1), 163-165. https://doi.org/10.1158/1055-9965.EPI-03-0102

@article{f9ba9323df1246e3be9aa6ebe9c5e53d,

title = "Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer",

abstract = "We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.",

author = "Oliver, \{Steven E.\} and Barney Barrass and Gunnell, \{David J.\} and Donovan, \{Jenny L.\} and Peters, \{Tim J.\} and Persad, \{Raj A.\} and David Gillatt and Neal, \{David E.\} and Hamdy, \{Freddie C.\} and Holly, \{Jeff M.P.\}",

year = "2004",

month = jan,

doi = "10.1158/1055-9965.EPI-03-0102",

language = "English",

volume = "13",

pages = "163--165",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research",

number = "1",

}

Oliver, SE, Barrass, B, Gunnell, DJ, Donovan, JL, Peters, TJ, Persad, RA, Gillatt, D, Neal, DE, Hamdy, FC & Holly, JMP 2004, 'Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 1, pp. 163-165. https://doi.org/10.1158/1055-9965.EPI-03-0102

Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer. / Oliver, Steven E.; Barrass, Barney; Gunnell, David J. et al.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 13, No. 1, 01.2004, p. 163-165.

Research output: Contribution to journal › Article › peer-review

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T1 - Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

AU - Oliver, Steven E.

AU - Barrass, Barney

AU - Gunnell, David J.

AU - Donovan, Jenny L.

AU - Peters, Tim J.

AU - Persad, Raj A.

AU - Gillatt, David

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Holly, Jeff M.P.

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N2 - We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

AB - We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

UR - https://www.scopus.com/pages/publications/9144268882

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DO - 10.1158/1055-9965.EPI-03-0102

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AN - SCOPUS:9144268882

SN - 1055-9965

VL - 13

SP - 163

EP - 165

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 1

ER -

Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

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