Serum oxidized low-density lipoprotein level and risk of cognitive impairment in older women

Alain Koyama, Katie Stone, Kristine Yaffe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated the association between serum level of oxidized low-density lipoprotein (oxLDL) and risk of cognitive impairment (dementia or mild cognitive impairment) among 572 nondemented community-dwelling women from a prospective cohort study of aging. After 5 years of follow-up, 228 (39.9%) developed cognitive impairment; and this did not differ by tertile of baseline oxLDL level (highest compared with lowest tertile 38.2% vs. 39.5%; odds ratio, 0.90; 95% confidence interval, 0.63–1.43). Multivariate adjustment produced similar results (odds ratio, 0.91; 95% confidence interval, 0.60 –1.39). These findings suggest that increased levels of serum oxLDL are not associated with a greater risk of incident cognitive impairment in older women.
Original languageEnglish
Pages (from-to)634-635e.2
Number of pages4
JournalNeurobiology of Aging
Volume34
Issue number2
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • dementia
  • Alzheimer’s disease
  • oxidized LDL
  • inflammation
  • Oxidative stress

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