Sex difference in diffuse malignant peritoneal mesothelioma

T. D. Yan, E. Popa, E. A. Brun, C. A. Cerruto, P. H. Sugarbaker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Background: Diffuse malignant peritoneal mesothelioma (DMPM) is rare and in the past has proved an invariably fetal disease. Female patients have been reported to have an improved survival outcome for reasons that are not understood. Methods: The survival of 34 men and 28 women who underwent cytoreduction and perioperative intraperitoneal chemotherapy for DMPM was compared. Twenty-five clinicopathological variables were subjected to univariate analysis. Results: The women had a 5-year survival rate of 63 per cent and median survival was not reached. The men had a 5-year survival rate of 42 per cent, with a median survival of 32 months (P = 0.045). Women had undergone more extensive previous surgery and had less extensive peritoneal involvement at the time of cytoreduction. Tumours in women more frequently showed a small nuclear size (30 μm or less) and the chromatin pattern was more often granular than clear. Conclusion: Women with DMPM had better survival. This observation may be related to the favourable clinical and histopathological features associated with women.

Original languageEnglish
Pages (from-to)1536-1542
Number of pages7
JournalBritish Journal of Surgery
Issue number12
Publication statusPublished - Dec 2006
Externally publishedYes


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