Sex differences in stroke

epidemiology, clinical presentation, medical care, and outcomes

Mathew J. Reeves*, Cheryl D. Bushnell, George Howard, Julia Warner Gargano, Pamela W. Duncan, Gwen Lynch, Arya Khatiwoda, Lynda Lisabeth

*Corresponding author for this work

Research output: Contribution to journalReview article

575 Citations (Scopus)

Abstract

Stroke has a greater effect on women than men because women have more events and are less likely to recover. Age-specific stroke rates are higher in men, but, because of their longer life expectancy and much higher incidence at older ages, women have more stroke events than men. With the exception of subarachnoid haemorrhage, there is little evidence of sex differences in stroke subtype or severity. Although several reports found that women are less likely to receive some in-hospital interventions, most differences disappear after age and comorbidities are accounted for. However, sex disparities persist in the use of thrombolytic treatment (with alteplase) and lipid testing. Functional outcomes and quality of life after stroke are consistently poorer in women, despite adjustment for baseline differences in age, prestroke function, and comorbidities. Here, we comprehensively review the epidemiology, clinical presentation, medical care, and outcomes of stroke in women.

Original languageEnglish
Pages (from-to)915-926
Number of pages12
JournalThe Lancet Neurology
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

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    Reeves, M. J., Bushnell, C. D., Howard, G., Gargano, J. W., Duncan, P. W., Lynch, G., ... Lisabeth, L. (2008). Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. The Lancet Neurology, 7(10), 915-926. https://doi.org/10.1016/S1474-4422(08)70193-5