Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress

Christina Mo, Thibault Renoir*, Terence Y C Pang, Anthony J. Hannan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive, psychiatric and motor decline, and is modifiable by unidentified environmental factors. We examined the effects of stress on cognitive function in R6/1 HD transgenic mice. Utilizing the Y-maze to assess short-term memory, we report that only female HD mice displayed vulnerability to 1. h of confinement stress reflected by impaired memory acquisition. This could not be attributed to a different corticosterone response or exploratory behaviour in the task. This is the first demonstration of increased stress susceptibility in an animal model of HD involving a direct negative impact on cognitive function.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalBehavioural Brain Research
Volume253
DOIs
Publication statusPublished - 5 Sep 2013
Externally publishedYes

Keywords

  • Acute stress
  • Corticosterone
  • Huntington's disease
  • Sexual dimorphism
  • Short-term memory
  • Y-maze

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