Signs of adaptation to trace metal contamination in a common urban bird

Samuel C. Andrew, Mark Patrick Taylor, Sarah Lundregan, Sigbjørn Lien, Henrik Jensen, Simon C. Griffith

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Metals and metalloids at elevated concentrations can be toxic to both humans and wildlife. In particular, lead exposure can act as a stressor to wildlife and cause negative effects on fitness. Any ability to adapt to stress caused by the negative effects of trace metal exposure would be beneficial for species living in contaminated environments. However, mechanisms for responding adaptively to metal contamination are not fully understood in free-living organisms. The Australian populations of the house sparrow (Passer domesticus) provides an excellent opportunity to study potential adaptation to environmental lead contamination because they have a commensal relationship with humans and are distributed broadly across Australian settlements including many long-term mining and smelting communities. To examine the potential for an evolutionary response to long-term lead exposure, we collected genomic SNP data using the house sparrow 200 K SNP array, from 11 localities across the Australian distribution including two mining sites (Broken Hill and Mount Isa, which are two genetically independent populations) that have well-established elevated levels of lead contamination as well as trace metals and metalloids. We contrast these known contaminated locations to other lesser-contaminated environments. Using an ecological association genome scan method to identify genomic differentiation associated with estimates of lead contamination we identified 60 outlier loci across three tests. A total of 39 genes were found to be physically linked (within 20 kbps) of all outliers in the house sparrow reference genome. The linked candidate genes included 12 genes relevant to lead exposure, such as two metal transporters that can transport metals including lead and zinc across cell membranes. These candidate genes provide targets for follow up experiments comparing resilience to lead exposure between populations exposed to varied levels of lead contamination.

LanguageEnglish
Pages679-686
Number of pages8
JournalScience of the Total Environment
Volume650
DOIs
Publication statusPublished - 10 Feb 2019

Fingerprint

Birds
trace metal
Contamination
Lead
Genes
bird
Metals
Metalloids
gene
metal
outlier
genomics
genome
commensal
smelting
Poisons
Smelting
Cell membranes
fitness
zinc

Keywords

  • lead exposure
  • avian
  • ecotoxicity
  • local adaptation
  • Passer domesticus

Cite this

Andrew, Samuel C. ; Taylor, Mark Patrick ; Lundregan, Sarah ; Lien, Sigbjørn ; Jensen, Henrik ; Griffith, Simon C. / Signs of adaptation to trace metal contamination in a common urban bird. In: Science of the Total Environment. 2019 ; Vol. 650. pp. 679-686.
@article{acbceecf53504890a5865a56a3e709dc,
title = "Signs of adaptation to trace metal contamination in a common urban bird",
abstract = "Metals and metalloids at elevated concentrations can be toxic to both humans and wildlife. In particular, lead exposure can act as a stressor to wildlife and cause negative effects on fitness. Any ability to adapt to stress caused by the negative effects of trace metal exposure would be beneficial for species living in contaminated environments. However, mechanisms for responding adaptively to metal contamination are not fully understood in free-living organisms. The Australian populations of the house sparrow (Passer domesticus) provides an excellent opportunity to study potential adaptation to environmental lead contamination because they have a commensal relationship with humans and are distributed broadly across Australian settlements including many long-term mining and smelting communities. To examine the potential for an evolutionary response to long-term lead exposure, we collected genomic SNP data using the house sparrow 200 K SNP array, from 11 localities across the Australian distribution including two mining sites (Broken Hill and Mount Isa, which are two genetically independent populations) that have well-established elevated levels of lead contamination as well as trace metals and metalloids. We contrast these known contaminated locations to other lesser-contaminated environments. Using an ecological association genome scan method to identify genomic differentiation associated with estimates of lead contamination we identified 60 outlier loci across three tests. A total of 39 genes were found to be physically linked (within 20 kbps) of all outliers in the house sparrow reference genome. The linked candidate genes included 12 genes relevant to lead exposure, such as two metal transporters that can transport metals including lead and zinc across cell membranes. These candidate genes provide targets for follow up experiments comparing resilience to lead exposure between populations exposed to varied levels of lead contamination.",
keywords = "lead exposure, avian, ecotoxicity, local adaptation, Passer domesticus",
author = "Andrew, {Samuel C.} and Taylor, {Mark Patrick} and Sarah Lundregan and Sigbj{\o}rn Lien and Henrik Jensen and Griffith, {Simon C.}",
year = "2019",
month = "2",
day = "10",
doi = "10.1016/j.scitotenv.2018.09.052",
language = "English",
volume = "650",
pages = "679--686",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

Signs of adaptation to trace metal contamination in a common urban bird. / Andrew, Samuel C.; Taylor, Mark Patrick; Lundregan, Sarah; Lien, Sigbjørn; Jensen, Henrik; Griffith, Simon C.

In: Science of the Total Environment, Vol. 650, 10.02.2019, p. 679-686.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Signs of adaptation to trace metal contamination in a common urban bird

AU - Andrew, Samuel C.

AU - Taylor, Mark Patrick

AU - Lundregan, Sarah

AU - Lien, Sigbjørn

AU - Jensen, Henrik

AU - Griffith, Simon C.

PY - 2019/2/10

Y1 - 2019/2/10

N2 - Metals and metalloids at elevated concentrations can be toxic to both humans and wildlife. In particular, lead exposure can act as a stressor to wildlife and cause negative effects on fitness. Any ability to adapt to stress caused by the negative effects of trace metal exposure would be beneficial for species living in contaminated environments. However, mechanisms for responding adaptively to metal contamination are not fully understood in free-living organisms. The Australian populations of the house sparrow (Passer domesticus) provides an excellent opportunity to study potential adaptation to environmental lead contamination because they have a commensal relationship with humans and are distributed broadly across Australian settlements including many long-term mining and smelting communities. To examine the potential for an evolutionary response to long-term lead exposure, we collected genomic SNP data using the house sparrow 200 K SNP array, from 11 localities across the Australian distribution including two mining sites (Broken Hill and Mount Isa, which are two genetically independent populations) that have well-established elevated levels of lead contamination as well as trace metals and metalloids. We contrast these known contaminated locations to other lesser-contaminated environments. Using an ecological association genome scan method to identify genomic differentiation associated with estimates of lead contamination we identified 60 outlier loci across three tests. A total of 39 genes were found to be physically linked (within 20 kbps) of all outliers in the house sparrow reference genome. The linked candidate genes included 12 genes relevant to lead exposure, such as two metal transporters that can transport metals including lead and zinc across cell membranes. These candidate genes provide targets for follow up experiments comparing resilience to lead exposure between populations exposed to varied levels of lead contamination.

AB - Metals and metalloids at elevated concentrations can be toxic to both humans and wildlife. In particular, lead exposure can act as a stressor to wildlife and cause negative effects on fitness. Any ability to adapt to stress caused by the negative effects of trace metal exposure would be beneficial for species living in contaminated environments. However, mechanisms for responding adaptively to metal contamination are not fully understood in free-living organisms. The Australian populations of the house sparrow (Passer domesticus) provides an excellent opportunity to study potential adaptation to environmental lead contamination because they have a commensal relationship with humans and are distributed broadly across Australian settlements including many long-term mining and smelting communities. To examine the potential for an evolutionary response to long-term lead exposure, we collected genomic SNP data using the house sparrow 200 K SNP array, from 11 localities across the Australian distribution including two mining sites (Broken Hill and Mount Isa, which are two genetically independent populations) that have well-established elevated levels of lead contamination as well as trace metals and metalloids. We contrast these known contaminated locations to other lesser-contaminated environments. Using an ecological association genome scan method to identify genomic differentiation associated with estimates of lead contamination we identified 60 outlier loci across three tests. A total of 39 genes were found to be physically linked (within 20 kbps) of all outliers in the house sparrow reference genome. The linked candidate genes included 12 genes relevant to lead exposure, such as two metal transporters that can transport metals including lead and zinc across cell membranes. These candidate genes provide targets for follow up experiments comparing resilience to lead exposure between populations exposed to varied levels of lead contamination.

KW - lead exposure

KW - avian

KW - ecotoxicity

KW - local adaptation

KW - Passer domesticus

UR - http://www.scopus.com/inward/record.url?scp=85053055179&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/arc/FT130101253

U2 - 10.1016/j.scitotenv.2018.09.052

DO - 10.1016/j.scitotenv.2018.09.052

M3 - Article

VL - 650

SP - 679

EP - 686

JO - Science of the Total Environment

T2 - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -