Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging

Kyung-Min Lee, Arup Neogi, Purnima Basu Neogi, Minjung Kim, Bongsoo Kim, Rafal Luchowski, Zygmunt Gryczynski, Nils Calander, Tae-Youl Choi

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    6 Citations (Scopus)
    22 Downloads (Pure)


    We present herein a silver nanostructure-assisted sensing platform which consists of a combined structure of Ag nanowire (NW) and nanodot (ND) array. Highly enhanced fluorescence from fluorophore is attributed to a strongly coupled optical near-field interaction between proximately located Ag NW and NDs. We obtained enhanced fluorescence intensity with up to 140 folds, as contrasted from background intensity, reaching a theoretical maximum value. On the other hand, fluorescence lifetime was greatly reduced to 0.27 ns (from 2.17 ns for the same fluorophores without nanostructure). This novel platform can be a promising utility for optical imaging and labeling of biological systems with a great sensitivity.
    Original languageEnglish
    Pages (from-to)056008-1-056008-5
    Number of pages5
    JournalJournal of Biomedical Optics
    Issue number5
    Publication statusPublished - 2011

    Bibliographical note

    Copyright 2011 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


    • Ag nanowire
    • Cell imaging
    • Fluorescence
    • Focused ion beam
    • Nanodot


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