Simultaneous concentration and separation of proteins in a nanochannel

David W. Inglis*, Ewa M. Goldys, Nils P. Calander

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Balancing the forces: Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low-salt side (-) balances the electro-osmotic force (blue) at the high-salt side (+).

Original languageEnglish
Pages (from-to)7546-7550
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number33
DOIs
Publication statusPublished - 8 Aug 2011

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