Simultaneous concentration and separation of proteins in a nanochannel

David W. Inglis; Ewa M. Goldys; Nils P. Calander

doi:10.1002/anie.201100236

Simultaneous concentration and separation of proteins in a nanochannel

David W. Inglis^*, Ewa M. Goldys, Nils P. Calander

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Balancing the forces: Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low-salt side (-) balances the electro-osmotic force (blue) at the high-salt side (+).

Original language	English
Pages (from-to)	7546-7550
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	33
DOIs	https://doi.org/10.1002/anie.201100236
Publication status	Published - 8 Aug 2011

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title = "Simultaneous concentration and separation of proteins in a nanochannel",

abstract = "Balancing the forces: Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low-salt side (-) balances the electro-osmotic force (blue) at the high-salt side (+).",

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year = "2011",

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AU - Inglis, David W.

AU - Goldys, Ewa M.

AU - Calander, Nils P.

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Y1 - 2011/8/8

N2 - Balancing the forces: Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low-salt side (-) balances the electro-osmotic force (blue) at the high-salt side (+).

AB - Balancing the forces: Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low-salt side (-) balances the electro-osmotic force (blue) at the high-salt side (+).

UR - https://www.scopus.com/pages/publications/79961218748

U2 - 10.1002/anie.201100236

DO - 10.1002/anie.201100236

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AN - SCOPUS:79961218748

SN - 1433-7851

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Simultaneous concentration and separation of proteins in a nanochannel

Abstract

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