Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera

Simona Ben-Haim*, Krzysztof Kacperski, Sharon Hain, Dean Van Gramberg, Brian F. Hutton, Kjell Erlandsson, Tali Sharir, Nathaniel Roth, Wendy A. Waddington, Daniel S. Berman, Peter J. Ell

*Corresponding author for this work

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Abstract

    Purpose: We compared simultaneous dual-radionuclide (DR) stress and rest myocardial perfusion imaging (MPI) with a novel solid-state cardiac camera and a conventional SPECT camera with separate stress and rest acquisitions. Methods: Of 27 consecutive patients recruited, 24 (64.5±11.8 years of age, 16 men) were injected with 74 MBq of 201Tl (rest) and 250 MBq 99mTc-MIBI (stress). Conventional MPI acquisition times for stress and rest are 21 min and 16 min, respectively. Rest 201Tl for 6 min and simultaneous DR 15-min list mode gated scans were performed on a D-SPECT cardiac scanner. In 11 patients DR D-SPECT was performed first and in 13 patients conventional stress 99mTc-MIBI SPECT imaging was performed followed by DR D-SPECT. The DR D-SPECT data were processed using a spill-over and scatter correction method. DR D-SPECT images were compared with rest 201Tl D-SPECT and with conventional SPECT images by visual analysis employing the 17-segment model and a five-point scale (0 normal, 4 absent) to calculate the summed stress and rest scores. Image quality was assessed on a four-point scale (1 poor, 4 very good) and gut activity was assessed on a four-point scale (0 none, 3 high). Results: Conventional MPI studies were abnormal at stress in 17 patients and at rest in 9 patients. In the 17 abnormal stress studies DR D-SPECT MPI showed 113 abnormal segments and conventional MPI showed 93 abnormal segments. In the nine abnormal rest studies DR D-SPECT showed 45 abnormal segments and conventional MPI showed 48 abnormal segments. The summed stress and rest scores on conventional SPECT and DR D-SPECT were highly correlated (r=0.9790 and 0.9694, respectively). The summed scores of rest 201Tl D-SPECT and DR-DSPECT were also highly correlated (r=0.9968, p<0.0001 for all). In six patients stress perfusion defects were significantly larger on stress DR D-SPECT images, and five of these patients were imaged earlier by D-SPECT than by conventional SPECT. Conclusion: Fast and high-quality simultaneous DR MPI is feasible with D-SPECT in a single imaging session with comparable diagnostic performance and image quality to conventional SPECT and to a separate rest 201Tl D-SPECT acquisition.

    Original languageEnglish
    Pages (from-to)1710-1721
    Number of pages12
    JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
    Volume37
    Issue number9
    DOIs
    Publication statusPublished - Aug 2010

    Keywords

    • Cardiac camera
    • Myocardial perfusion imaging
    • Simultaneous dual-radionuclide acquisition
    • Solid state detectors

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