Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Hampus Andersson; Alexander Bremer; Florin Gandor; Georg Ebersbach; Matthias Löhle; Per Odin; Alexander Storch

doi:10.1002/mdc3.70061

Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Hampus Andersson, Alexander Bremer, Florin Gandor, Georg Ebersbach, Matthias Löhle, Per Odin, Alexander Storch

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.

Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).

Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.

Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.

Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

Original language	English
Number of pages	6
Journal	Movement Disorders Clinical Practice
DOIs	https://doi.org/10.1002/mdc3.70061
Publication status	E-pub ahead of print - 3 Apr 2025
Externally published	Yes

Keywords

motor fluctuations
nonmotor symptoms
Parkinson's disease
PD home motor diary
validity

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10.1002/mdc3.70061Licence: CC BY

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title = "Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary",

abstract = "Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.",

keywords = "motor fluctuations, nonmotor symptoms, Parkinson's disease, PD home motor diary, validity",

author = "Hampus Andersson and Alexander Bremer and Florin Gandor and Georg Ebersbach and Matthias L{\"o}hle and Per Odin and Alexander Storch",

year = "2025",

month = apr,

day = "3",

doi = "10.1002/mdc3.70061",

language = "English",

journal = "Movement Disorders Clinical Practice",

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T1 - Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

AU - Andersson, Hampus

AU - Bremer, Alexander

AU - Gandor, Florin

AU - Ebersbach, Georg

AU - Löhle, Matthias

AU - Odin, Per

AU - Storch, Alexander

PY - 2025/4/3

Y1 - 2025/4/3

N2 - Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

AB - Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

KW - motor fluctuations

KW - nonmotor symptoms

KW - Parkinson's disease

KW - PD home motor diary

KW - validity

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U2 - 10.1002/mdc3.70061

DO - 10.1002/mdc3.70061

M3 - Article

C2 - 40178037

SN - 2330-1619

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

ER -

Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Abstract

Keywords

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