Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Hampus Andersson; Alexander Bremer; Florin Gandor; Georg Ebersbach; Matthias Löhle; Per Odin; Alexander Storch

doi:10.1002/mdc3.70061

Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Hampus Andersson, Alexander Bremer, Florin Gandor, Georg Ebersbach, Matthias Löhle, Per Odin, Alexander Storch

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Abstract

Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.

Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).

Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.

Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.

Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

Original language	English
Pages (from-to)	979-984
Number of pages	6
Journal	Movement Disorders Clinical Practice
Volume	12
Issue number	7
Early online date	3 Apr 2025
DOIs	https://doi.org/10.1002/mdc3.70061
Publication status	Published - Jul 2025
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

motor fluctuations
nonmotor symptoms
Parkinson's disease
PD home motor diary
validity

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Publisher version (open access)Final published version, 493 KBLicence: CC BY

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title = "Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary",

abstract = "Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states. Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.",

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author = "Hampus Andersson and Alexander Bremer and Florin Gandor and Georg Ebersbach and Matthias L{\"o}hle and Per Odin and Alexander Storch",

note = "Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

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doi = "10.1002/mdc3.70061",

language = "English",

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T1 - Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

AU - Andersson, Hampus

AU - Bremer, Alexander

AU - Gandor, Florin

AU - Ebersbach, Georg

AU - Löhle, Matthias

AU - Odin, Per

AU - Storch, Alexander

N1 - Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2025/7

Y1 - 2025/7

N2 - Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states. Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

AB - Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states. Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

KW - motor fluctuations

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KW - Parkinson's disease

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KW - validity

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SN - 2330-1619

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JO - Movement Disorders Clinical Practice

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Simultaneous nonmotor symptoms do not affect general validity but interpretation of the Parkinson's disease motor diary

Abstract

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