Simultaneous orthogonal methods for the real-time analysis of catalytic reactions

Robin Theron, Yang Wu, Lars P. E. Yunker, Amelia V. Hesketh, Indrek Pernik, Andrew S. Weller, J. Scott McIndoe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Continuous monitoring of catalyzed reactions using infrared spectroscopy (IR) measures the transformation of reactant into product, whereas mass spectrometry delineates the dynamics of the catalytically relevant species present at much lower concentrations, a holistic approach that provides mechanistic insight into the reaction components whose abundance spans 5 orders of magnitude. Probing reactions to this depth reveals entities that include precatalysts, resting states, intermediates, and also catalyst impurities and decomposition products. Simple temporal profiles that arise from this analysis aid discrimination between the different types of species, and a hydroacylation reaction catalyzed by a cationic rhodium complex is studied in detail to provide a test case for the utility of this methodology.

Original languageEnglish
Pages (from-to)6911-6917
Number of pages7
JournalACS Catalysis
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

Keywords

  • mass spectrometry
  • infrared spectroscopy
  • real-time monitoring
  • catalysis
  • hydroacylation

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