Single cell mass measurement from deformation of nanofork

Md. Fazly Rabby Akash; Md. Al-Amin Sheikh; Md. Habibur Rahman; Mohd Ridzuan Ahmad

doi:10.1109/ICIVPR.2017.7890863

Single cell mass measurement from deformation of nanofork

Md. Fazly Rabby Akash, Md. Al-Amin Sheikh, Md. Habibur Rahman, Mohd Ridzuan Ahmad

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

A great revolution in health science could be done if the disease could be diagnosis at very early stage. The conventional chemically manipulated biological analysis of group cells is not able to illustrate the fundamental properties of a cell such as cell proliferations, cell growths, cell damage and electro-mechanical properties. In this paper, we are representing a method to measure the mass of a single cell using the deformation of a nanofork (which will pick the cell form a line array substrate). We have used Newton's third law related with the deformation angle caused by the moment of inertia (as the fork will bend downward). Silicon is used as a base material of the nanofork. Firstly, the nanofork is inserted into the line array substrate then it picks up the cell to the upwards creating a deformation of the nanofork because of the cell weight. Then deformation angle is calculated form simulation result. For the experimental purpose we have used cell size is 5 μm. We observed the deformation angle 0.4 μm form the simulation result. Which is sufficient to find out the mass of the cell. Using the deformation angle and the related equations we have measured the mass of a single cell 0.16 pg. This result is very consistent with the previously reported single yeast cell mass.

Original language	English
Title of host publication	2017 IEEE International Conference on Imaging, Vision and Pattern Recognition (icIVPR)
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Number of pages	4
ISBN (Electronic)	9781509060030
DOIs	https://doi.org/10.1109/ICIVPR.2017.7890863
Publication status	Published - 30 Mar 2017
Externally published	Yes
Event	2017 IEEE International Conference on Imaging, Vision and Pattern Recognition, icIVPR 2017 - Dhaka, Bangladesh Duration: 13 Feb 2017 → 14 Feb 2017

Other

Other	2017 IEEE International Conference on Imaging, Vision and Pattern Recognition, icIVPR 2017
Country/Territory	Bangladesh
City	Dhaka
Period	13/02/17 → 14/02/17

Keywords

deformation angle
line array substrate
nanofork
Single Cell Mass (SCM)

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10.1109/ICIVPR.2017.7890863

Cite this

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title = "Single cell mass measurement from deformation of nanofork",

abstract = "A great revolution in health science could be done if the disease could be diagnosis at very early stage. The conventional chemically manipulated biological analysis of group cells is not able to illustrate the fundamental properties of a cell such as cell proliferations, cell growths, cell damage and electro-mechanical properties. In this paper, we are representing a method to measure the mass of a single cell using the deformation of a nanofork (which will pick the cell form a line array substrate). We have used Newton's third law related with the deformation angle caused by the moment of inertia (as the fork will bend downward). Silicon is used as a base material of the nanofork. Firstly, the nanofork is inserted into the line array substrate then it picks up the cell to the upwards creating a deformation of the nanofork because of the cell weight. Then deformation angle is calculated form simulation result. For the experimental purpose we have used cell size is 5 μm. We observed the deformation angle 0.4 μm form the simulation result. Which is sufficient to find out the mass of the cell. Using the deformation angle and the related equations we have measured the mass of a single cell 0.16 pg. This result is very consistent with the previously reported single yeast cell mass.",

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Akash, MFR, Sheikh, MA-A, Rahman, MH & Ahmad, MR 2017, Single cell mass measurement from deformation of nanofork. in 2017 IEEE International Conference on Imaging, Vision and Pattern Recognition (icIVPR)., 7890863, Institute of Electrical and Electronics Engineers (IEEE), 2017 IEEE International Conference on Imaging, Vision and Pattern Recognition, icIVPR 2017, Dhaka, Bangladesh, 13/02/17. https://doi.org/10.1109/ICIVPR.2017.7890863

Single cell mass measurement from deformation of nanofork. / Akash, Md. Fazly Rabby; Sheikh, Md. Al-Amin; Rahman, Md. Habibur et al.
2017 IEEE International Conference on Imaging, Vision and Pattern Recognition (icIVPR). Institute of Electrical and Electronics Engineers (IEEE), 2017. 7890863.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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AU - Sheikh, Md. Al-Amin

AU - Rahman, Md. Habibur

AU - Ahmad, Mohd Ridzuan

PY - 2017/3/30

Y1 - 2017/3/30

N2 - A great revolution in health science could be done if the disease could be diagnosis at very early stage. The conventional chemically manipulated biological analysis of group cells is not able to illustrate the fundamental properties of a cell such as cell proliferations, cell growths, cell damage and electro-mechanical properties. In this paper, we are representing a method to measure the mass of a single cell using the deformation of a nanofork (which will pick the cell form a line array substrate). We have used Newton's third law related with the deformation angle caused by the moment of inertia (as the fork will bend downward). Silicon is used as a base material of the nanofork. Firstly, the nanofork is inserted into the line array substrate then it picks up the cell to the upwards creating a deformation of the nanofork because of the cell weight. Then deformation angle is calculated form simulation result. For the experimental purpose we have used cell size is 5 μm. We observed the deformation angle 0.4 μm form the simulation result. Which is sufficient to find out the mass of the cell. Using the deformation angle and the related equations we have measured the mass of a single cell 0.16 pg. This result is very consistent with the previously reported single yeast cell mass.

AB - A great revolution in health science could be done if the disease could be diagnosis at very early stage. The conventional chemically manipulated biological analysis of group cells is not able to illustrate the fundamental properties of a cell such as cell proliferations, cell growths, cell damage and electro-mechanical properties. In this paper, we are representing a method to measure the mass of a single cell using the deformation of a nanofork (which will pick the cell form a line array substrate). We have used Newton's third law related with the deformation angle caused by the moment of inertia (as the fork will bend downward). Silicon is used as a base material of the nanofork. Firstly, the nanofork is inserted into the line array substrate then it picks up the cell to the upwards creating a deformation of the nanofork because of the cell weight. Then deformation angle is calculated form simulation result. For the experimental purpose we have used cell size is 5 μm. We observed the deformation angle 0.4 μm form the simulation result. Which is sufficient to find out the mass of the cell. Using the deformation angle and the related equations we have measured the mass of a single cell 0.16 pg. This result is very consistent with the previously reported single yeast cell mass.

KW - deformation angle

KW - line array substrate

KW - nanofork

KW - Single Cell Mass (SCM)

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M3 - Conference proceeding contribution

AN - SCOPUS:85018184756

BT - 2017 IEEE International Conference on Imaging, Vision and Pattern Recognition (icIVPR)

PB - Institute of Electrical and Electronics Engineers (IEEE)

T2 - 2017 IEEE International Conference on Imaging, Vision and Pattern Recognition, icIVPR 2017

Y2 - 13 February 2017 through 14 February 2017

ER -

Single cell mass measurement from deformation of nanofork

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