TY - JOUR
T1 - Sleep deprivation and neurological disorders
AU - Bishir, Muhammed
AU - Bhat, Abid
AU - Essa, Musthafa Mohamed
AU - Ekpo, Okobi
AU - Ihunwo, Amadi O.
AU - Veeraraghavan, Vishnu Priya
AU - Mohan, Surapaneni Krishna
AU - Mahalakshmi, Arehally M.
AU - Ray, Bipul
AU - Tuladhar, Sunanda
AU - Chang, Sulie
AU - Chidambaram, Saravana Babu
AU - Sakharkar, Meena Kishore
AU - Guillemin, Gilles J.
AU - Qoronfleh, M. Walid
AU - Ojcius, David J.
N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2020/11/23
Y1 - 2020/11/23
N2 - Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended.
AB - Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended.
UR - http://www.scopus.com/inward/record.url?scp=85098596307&partnerID=8YFLogxK
U2 - 10.1155/2020/5764017
DO - 10.1155/2020/5764017
M3 - Review article
C2 - 33381558
AN - SCOPUS:85098596307
SN - 2314-6133
VL - 2020
SP - 1
EP - 19
JO - BioMed Research International
JF - BioMed Research International
M1 - 5764017
ER -