Sleep disturbance in mild cognitive impairment Is associated with alterations in the brain's default mode network

Andrew C. McKinnon, Jim Lagopoulos, Zoe Terpening, Ron Grunstein, Ian B. Hickie, Jennifer Batchelor, Simon J G Lewis, Shantel Duffy, James M. Shine, Sharon L. Naismith

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study aimed to identify default mode network (DMN) functional connectivity deficits in patients with mild cognitive impairment (MCI) and sleep disturbance, relative to those with MCI and no sleep disturbance. A control group was included to aid in identifying DMN changes specific to MCI. A cross-sectional, single-center study was performed at the Brain and Mind Research Centre in Sydney, Australia. Participants (95 adults over the age of 65: 38 controls and 57 meeting criteria for MCI) underwent resting-state functional MRI along with comprehensive neuropsychological, medical, and psychiatric assessment. Self-report data were collected including sleep quality assessment via the Pittsburgh Sleep Quality Index. A total score of greater than 5 on the Pittsburgh Sleep Quality Index was used to signify the presence of significant sleep disturbance, as per commonly used methodology. Using this criterion, 53% (n = 30) of our MCI group were classified as sleep-disturbed. Whereas the total group of MCI subjects and controls demonstrated no significant differences, sleep-disturbed MCIs demonstrated increased connectivity between temporal and parietal regions, and decreased connectivity between the prefrontal cortex and the temporoparietal junction relative to sleep-disturbed controls. Relative to those MCIs without sleep disturbance, sleep-disturbed MCI participants demonstrated significantly diminished DMN connectivity between temporal and parietal regions, a finding that was particularly pronounced in amnestic MCI. Sleep disturbance in MCI is associated with distinct alterations in DMN functional connectivity in brain regions underpinning salient memory and sleep systems. Future studies may build on these results via experimental manipulation and objective measurement of sleep.

LanguageEnglish
Pages305-315
Number of pages11
JournalBehavioral Neuroscience
Volume130
Issue number3
DOIs
Publication statusPublished - 1 Jun 2016

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Sleep
Brain
Parietal Lobe
Temporal Lobe
Cognitive Dysfunction
Prefrontal Cortex
Self Report
Psychiatry
Magnetic Resonance Imaging
Control Groups

Cite this

McKinnon, A. C., Lagopoulos, J., Terpening, Z., Grunstein, R., Hickie, I. B., Batchelor, J., ... Naismith, S. L. (2016). Sleep disturbance in mild cognitive impairment Is associated with alterations in the brain's default mode network. Behavioral Neuroscience, 130(3), 305-315. https://doi.org/10.1037/bne0000137
McKinnon, Andrew C. ; Lagopoulos, Jim ; Terpening, Zoe ; Grunstein, Ron ; Hickie, Ian B. ; Batchelor, Jennifer ; Lewis, Simon J G ; Duffy, Shantel ; Shine, James M. ; Naismith, Sharon L. / Sleep disturbance in mild cognitive impairment Is associated with alterations in the brain's default mode network. In: Behavioral Neuroscience. 2016 ; Vol. 130, No. 3. pp. 305-315.
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McKinnon, AC, Lagopoulos, J, Terpening, Z, Grunstein, R, Hickie, IB, Batchelor, J, Lewis, SJG, Duffy, S, Shine, JM & Naismith, SL 2016, 'Sleep disturbance in mild cognitive impairment Is associated with alterations in the brain's default mode network', Behavioral Neuroscience, vol. 130, no. 3, pp. 305-315. https://doi.org/10.1037/bne0000137

Sleep disturbance in mild cognitive impairment Is associated with alterations in the brain's default mode network. / McKinnon, Andrew C.; Lagopoulos, Jim; Terpening, Zoe; Grunstein, Ron; Hickie, Ian B.; Batchelor, Jennifer; Lewis, Simon J G; Duffy, Shantel; Shine, James M.; Naismith, Sharon L.

In: Behavioral Neuroscience, Vol. 130, No. 3, 01.06.2016, p. 305-315.

Research output: Contribution to journalArticleResearchpeer-review

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