Sleep disturbances in parkinson disease and their potential role in heterogeneity

David G. Gunn, Sharon L. Naismith, Simon J G Lewis

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Parkinson disease (PD) is commonly conceptualized as a movement disorder. Most previous attempts to define the heterogeneity of the condition have used prospective methods based on arbitrary features such as motor symptoms or age of disease onset. However, nonmotor symptoms including neuropsychological, neuropsychiatric, and behavioral impairments have received less attention. Sleep disturbances are extremely common in PD and appear to be associated with cognitive and psychiatric problems. Recent research has begun to elucidate the links between these variables, but the origin and extent of these relationships are not clearly understood. This review outlines the importance of sleep for healthy cognition and mood, highlighting the possible implications that disturbed sleep may have with regard to patients with PD. It also emphasizes the need for further studies that explore the heterogeneity of all disease features in PD.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalJournal of Geriatric Psychiatry and Neurology
Volume23
Issue number2
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • Cognitive impairment
  • Depression
  • Heterogeneity
  • Parkinson disease
  • Sleep disorders

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