TY - JOUR
T1 - Sleep-wake changes and cognition in neurodegenerative disease
AU - Naismith, Sharon L.
AU - Lewis, Simon J G
AU - Rogers, Naomi L.
PY - 2011
Y1 - 2011
N2 - With the increasing aging population, neurodegenerative disorders will become more common in clinical practice. These disorders involve multiple pathophysiological mechanisms that differentially affect cognition, mood, and physical functions. Possibly due to the involvement of common underlying neurobiological circuits, sleep and/or circadian (sleep-wake) changes are also common in this disease group. Of significance, sleep-wake changes are often a prodromal feature and are predictive of cognitive decline, psychiatric symptoms, quality of life, need for institutional care, and caregiver burden. Unfortunately, in neurodegenerative disease, few studies have included detailed polysomnography or neuropsychological assessments although some data indicate that sleep and neurocognitive features are related. Further studies are also required to address the effects of pharmacological and nonpharmacological treatments on cognitive functioning. Such research will hopefully lead to targeted early intervention approaches for cognitive decline in older people.
AB - With the increasing aging population, neurodegenerative disorders will become more common in clinical practice. These disorders involve multiple pathophysiological mechanisms that differentially affect cognition, mood, and physical functions. Possibly due to the involvement of common underlying neurobiological circuits, sleep and/or circadian (sleep-wake) changes are also common in this disease group. Of significance, sleep-wake changes are often a prodromal feature and are predictive of cognitive decline, psychiatric symptoms, quality of life, need for institutional care, and caregiver burden. Unfortunately, in neurodegenerative disease, few studies have included detailed polysomnography or neuropsychological assessments although some data indicate that sleep and neurocognitive features are related. Further studies are also required to address the effects of pharmacological and nonpharmacological treatments on cognitive functioning. Such research will hopefully lead to targeted early intervention approaches for cognitive decline in older people.
KW - Aging
KW - Cognition
KW - Dementia
KW - Depression
KW - Neurodegenerative disease
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=79955397482&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-53817-8.00002-5
DO - 10.1016/B978-0-444-53817-8.00002-5
M3 - Article
C2 - 21531243
AN - SCOPUS:79955397482
VL - 190
SP - 21
EP - 52
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
ER -