Smooth muscle cell and arterial aging: basic and clinical aspects

Patrick Lacolley*, Veronique Regnault, Alberto P. Avolio

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    86 Citations (Scopus)

    Abstract

    Arterial aging engages a plethora of key signalling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and extracellular matrix degradation responsible for alterations of the mechanical properties of the vascular wall. This review highlights proof-of-concept examples of components of the extracellular matrix, VSMC receptors which connect extracellular and intracellular structures, and signalling pathways regulating changes in mechanotransduction and vascular homeostasis in aging. Furthermore, it provides a new framework for understanding how VSMC stiffness and adhesion to extracellular matrix contribute to arterial stiffness and how interactions with endothelial cells, platelets, and immune cells can regulate vascular aging. The identification of the key players of VSMC changes operating in large and small-sized arteries in response to increased mechanical load may be useful to better elucidate the causes and consequences of vascular aging and associated progression of hypertension, arteriosclerosis, and atherosclerosis.

    Original languageEnglish
    Pages (from-to)513-528
    Number of pages16
    JournalCardiovascular Research
    Volume114
    Issue number4
    DOIs
    Publication statusPublished - 15 Mar 2018

    Keywords

    • Arterial aging
    • Mechanobiology
    • Mechanotransduction
    • Vascular smooth muscle cell

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