SNPing at the epidermal barrier

David P. Kelsell; Carolyn Byrne

doi:10.1038/jid.2011.92

SNPing at the epidermal barrier

David P. Kelsell, Carolyn Byrne

Research output: Contribution to journal › Letter

13 Citations (Scopus)

Abstract

Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.

Original language	English
Pages (from-to)	1593-1595
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	131
Issue number	8
DOIs	https://doi.org/10.1038/jid.2011.92
Publication status	Published - 2011
Externally published	Yes

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10.1038/jid.2011.92

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title = "SNPing at the epidermal barrier",

abstract = "Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.",

author = "Kelsell, {David P.} and Carolyn Byrne",

year = "2011",

doi = "10.1038/jid.2011.92",

language = "English",

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T1 - SNPing at the epidermal barrier

AU - Kelsell, David P.

AU - Byrne, Carolyn

PY - 2011

Y1 - 2011

N2 - Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.

AB - Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.

U2 - 10.1038/jid.2011.92

DO - 10.1038/jid.2011.92

M3 - Letter

C2 - 21753762

SN - 0022-202X

VL - 131

SP - 1593

EP - 1595

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 8

ER -

SNPing at the epidermal barrier

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