Social and emotional functions in three patients with medial frontal lobe damage including the anterior cingulate cortex

Amee Baird, Bonnie Kate Dewar, Hugo Critchley, Ray Dolan, Tim Shallice, Lisa Cipolotti

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction. The aim of this study was to explore social and emotional functions in patients with medial frontal damage including the anterior cingulate cortex (ACC). Methods. Three patients with medial frontal lobe lesions primarily involving the ACC performed tasks on motivational decision making, emotional facial expression recognition, and social cognition, including theory of mind (ToM). Their performance on these tasks was compared with age and education matched healthy controls. Results. Patient performance on the motivational decision making and social situations tasks did not differ from controls. Selective emotional facial expression recognition impairment for fear was evident in one patient with a unilateral right ACC lesion (patient 3). ToM impairment was present in only one patient with a bilateral ACC lesion (patient 2). In contrast, the two patients with unilateral right ACC lesions had intact ToM (patients 1 and 3). Conclusions. These findings suggest that medial frontal lobe lesions primarily involving the ACC do not appear to critically disrupt motivational decision making or social situation processing. The ACC plays a role in processing particular types of emotion (fear). Bilateral ACC damage impairs ToM processing, but unilateral damage to the right ACC is not sufficient to disrupt ToM.

LanguageEnglish
Pages369-388
Number of pages20
JournalCognitive Neuropsychiatry
Volume11
Issue number4
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

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Gyrus Cinguli
Frontal Lobe
Theory of Mind
Decision Making
Facial Expression
Fear
Task Performance and Analysis
Cognition
Emotions
Education

Cite this

Baird, Amee ; Dewar, Bonnie Kate ; Critchley, Hugo ; Dolan, Ray ; Shallice, Tim ; Cipolotti, Lisa. / Social and emotional functions in three patients with medial frontal lobe damage including the anterior cingulate cortex. In: Cognitive Neuropsychiatry. 2006 ; Vol. 11, No. 4. pp. 369-388.
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abstract = "Introduction. The aim of this study was to explore social and emotional functions in patients with medial frontal damage including the anterior cingulate cortex (ACC). Methods. Three patients with medial frontal lobe lesions primarily involving the ACC performed tasks on motivational decision making, emotional facial expression recognition, and social cognition, including theory of mind (ToM). Their performance on these tasks was compared with age and education matched healthy controls. Results. Patient performance on the motivational decision making and social situations tasks did not differ from controls. Selective emotional facial expression recognition impairment for fear was evident in one patient with a unilateral right ACC lesion (patient 3). ToM impairment was present in only one patient with a bilateral ACC lesion (patient 2). In contrast, the two patients with unilateral right ACC lesions had intact ToM (patients 1 and 3). Conclusions. These findings suggest that medial frontal lobe lesions primarily involving the ACC do not appear to critically disrupt motivational decision making or social situation processing. The ACC plays a role in processing particular types of emotion (fear). Bilateral ACC damage impairs ToM processing, but unilateral damage to the right ACC is not sufficient to disrupt ToM.",
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Social and emotional functions in three patients with medial frontal lobe damage including the anterior cingulate cortex. / Baird, Amee; Dewar, Bonnie Kate; Critchley, Hugo; Dolan, Ray; Shallice, Tim; Cipolotti, Lisa.

In: Cognitive Neuropsychiatry, Vol. 11, No. 4, 07.2006, p. 369-388.

Research output: Contribution to journalArticleResearchpeer-review

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