Solid-binding peptides in biomedicine

Andrew Care, Peter L. Bergquist, Anwar Sunna

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Some peptides are able to bind to inorganic materials such as silica and gold. Over the past decade, Solid-binding peptides (SBPs) have been used increasingly as molecular building blocks in nanobiotechnology. These peptides show selectivity and bind with high affinity to a diverse range of inorganic surfaces e.g. metals, metal oxides, metal compounds, magnetic materials, semiconductors, carbon materials, polymers and minerals. They can be used in applications such as protein purification and synthesis, assembly and the functionalization of nanomaterials. They offer simple and versatile bioconjugation methods that can increase biocompatibility and also direct the immobilization and orientation of nanoscale entities onto solid supports without impeding their functionality. SBPs have been employed in numerous nanobiotechnological applications such as the controlled synthesis of nanomaterials and nanostructures, formation of hybrid biomaterials, immobilization of functional proteins and improved nanomaterial biocompatibility. With advances in nanotechnology, a multitude of novel nanomaterials have been designed and synthesized for diagnostic and therapeutic applications. New approaches have been developed recently to exert a greater control over bioconjugation and eventually, over the optimal and functional display of biomolecules on the surfaces of many types of solid materials. In this chapter we describe SBPs and highlight some selected examples of their potential applications in biomedicine.

LanguageEnglish
Title of host publicationPeptides and Peptide-based Biomaterials and their Biomedical Applications
EditorsAnwar Sunna, Andrew Care, Peter L. Bergquist
Place of PublicationCham, Switzerland
PublisherSpringer, Springer Nature
Chapter2
Pages21-36
Number of pages16
ISBN (Electronic)9783319660950
ISBN (Print)9783319660943
DOIs
Publication statusPublished - 2017

Publication series

NameAdvances in experimental medicine and biology
PublisherSpringer
Volume1030
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Nanostructures
Nanostructured materials
Peptides
Metals
Biocompatibility
Immobilization
Nanobiotechnology
Semiconductors
Nanotechnology
Magnetic materials
Biocompatible Materials
Biomolecules
Silicon Dioxide
Gold
Oxides
Purification
Minerals
Polymers
Proteins
Carbon

Keywords

  • bioconjugation
  • biomaterials
  • functionalization
  • biomedicine
  • solid-binding peptides

Cite this

Care, A., Bergquist, P. L., & Sunna, A. (2017). Solid-binding peptides in biomedicine. In A. Sunna, A. Care, & P. L. Bergquist (Eds.), Peptides and Peptide-based Biomaterials and their Biomedical Applications (pp. 21-36). (Advances in experimental medicine and biology; Vol. 1030). Cham, Switzerland: Springer, Springer Nature. Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-3-319-66095-0_2
Care, Andrew ; Bergquist, Peter L. ; Sunna, Anwar. / Solid-binding peptides in biomedicine. Peptides and Peptide-based Biomaterials and their Biomedical Applications. editor / Anwar Sunna ; Andrew Care ; Peter L. Bergquist. Cham, Switzerland : Springer, Springer Nature, 2017. pp. 21-36 (Advances in experimental medicine and biology). (Advances in Experimental Medicine and Biology).
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Care, A, Bergquist, PL & Sunna, A 2017, Solid-binding peptides in biomedicine. in A Sunna, A Care & PL Bergquist (eds), Peptides and Peptide-based Biomaterials and their Biomedical Applications. Advances in experimental medicine and biology, vol. 1030, Springer, Springer Nature, Cham, Switzerland, Advances in Experimental Medicine and Biology, pp. 21-36. https://doi.org/10.1007/978-3-319-66095-0_2

Solid-binding peptides in biomedicine. / Care, Andrew; Bergquist, Peter L.; Sunna, Anwar.

Peptides and Peptide-based Biomaterials and their Biomedical Applications. ed. / Anwar Sunna; Andrew Care; Peter L. Bergquist. Cham, Switzerland : Springer, Springer Nature, 2017. p. 21-36 (Advances in experimental medicine and biology; Vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Care A, Bergquist PL, Sunna A. Solid-binding peptides in biomedicine. In Sunna A, Care A, Bergquist PL, editors, Peptides and Peptide-based Biomaterials and their Biomedical Applications. Cham, Switzerland: Springer, Springer Nature. 2017. p. 21-36. (Advances in experimental medicine and biology). (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-66095-0_2