Solid-binding peptides in biomedicine

Andrew Care, Peter L. Bergquist, Anwar Sunna*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Citations (Scopus)


Some peptides are able to bind to inorganic materials such as silica and gold. Over the past decade, Solid-binding peptides (SBPs) have been used increasingly as molecular building blocks in nanobiotechnology. These peptides show selectivity and bind with high affinity to a diverse range of inorganic surfaces e.g. metals, metal oxides, metal compounds, magnetic materials, semiconductors, carbon materials, polymers and minerals. They can be used in applications such as protein purification and synthesis, assembly and the functionalization of nanomaterials. They offer simple and versatile bioconjugation methods that can increase biocompatibility and also direct the immobilization and orientation of nanoscale entities onto solid supports without impeding their functionality. SBPs have been employed in numerous nanobiotechnological applications such as the controlled synthesis of nanomaterials and nanostructures, formation of hybrid biomaterials, immobilization of functional proteins and improved nanomaterial biocompatibility. With advances in nanotechnology, a multitude of novel nanomaterials have been designed and synthesized for diagnostic and therapeutic applications. New approaches have been developed recently to exert a greater control over bioconjugation and eventually, over the optimal and functional display of biomolecules on the surfaces of many types of solid materials. In this chapter we describe SBPs and highlight some selected examples of their potential applications in biomedicine.

Original languageEnglish
Title of host publicationPeptides and Peptide-based Biomaterials and their Biomedical Applications
EditorsAnwar Sunna, Andrew Care, Peter L. Bergquist
Place of PublicationCham, Switzerland
PublisherSpringer, Springer Nature
Number of pages16
ISBN (Electronic)9783319660950
ISBN (Print)9783319660943
Publication statusPublished - 2017

Publication series

NameAdvances in experimental medicine and biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • bioconjugation
  • biomaterials
  • functionalization
  • biomedicine
  • solid-binding peptides


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