Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

Sajid Bashir, Rai M. Sarfraz*, Husnain Ahmad, Muhammad R. Akram, Muhammad N. Qaisar, Muhammad R. Ali, Muhammad U. Khan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.

Original languageEnglish
Pages (from-to)1000-1008
Number of pages9
JournalLatin American Journal of Pharmacy
Volume39
Issue number5
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Bioavailability
  • Simvastatin
  • Solid dispersion
  • Solubility
  • Solvent evaporation

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