Abstract
This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.
Original language | English |
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Pages (from-to) | 1000-1008 |
Number of pages | 9 |
Journal | Latin American Journal of Pharmacy |
Volume | 39 |
Issue number | 5 |
Publication status | Published - 2020 |
Externally published | Yes |
Keywords
- Bioavailability
- Simvastatin
- Solid dispersion
- Solubility
- Solvent evaporation