Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.