The emergence and growth of research in cognitive neuroscience over recent decades has led to important discoveries about how the brain and mind work. These discoveries have potential implications for the use of educational technologies and provide insight into possibilities for improving student learning in digital environments. Despite the promise of the emerging field of educational neuroscience, it is difficult to translate findings from the laboratory to the physical or virtual classroom. The articles in this special issue of AJET are attempts to bridge this gap. We hope that this special issue will serve as a catalyst for further work on the translation of foundational research on the brain and mind to learning design and teaching with educational technologies.