Spectrophotometric multivariate calibration approach: application in quantitative determination of mebeverine in bulk drug and pharmaceutical formulations

Farhan Ahmed Siddiqui*, Nawab Sher, Najmul Hasan, Nighat Shafi, Hina Shamshad, Mansoor Ali Beg, Ali Akbar Sial, Alisha Wafa Sial

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Multivariate calibration technique using spectrophotometer is underway to assess quantitatively mebeverine in intermediate and fished stage of different dosage forms of pharmaceutical. This approach bases on the use of linear regression analysis equation by using correlation of concentration of drugs and corresponding absorbance taken, at five unlike wavelengths. Statistical evaluation of the results finds the method to be highly accurate, precise and reproducible. Drug molecule was studied in concentration range of 5-80 μg/mL and correlation coefficient(r) of 0.9966 was obtained. Proposed method was found to have considerable resolving power, rapidity, sensitivity and low cost for the quantification of the drugs analysis, in quality control samples and schedule analysis of subject compounds. Common excipients like magnesium stearate, Pyrrolidone K 30, lactose and hydroxypropylmethylcellulose were studied and no interference wascountered. This approach was highly useful in eliminating the common error that comes from experimental design or instruments errors.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalWorld Applied Sciences Journal
Volume32
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Mebeverine
  • Multivariate
  • Pharmaceuticlas

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