Spectroscopic signatures of an Fmoc-tetrapeptide, Fmoc and fluorene

Yi Zou, Kasra Razmkhah, Nikola P. Chmel, Ian W. Hamley, Alison Rodger*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The hydrophobic Fmoc [N-(fluorenyl)-9-methoxycarbonyl] unit is often conjugated to peptides to confer amphiphilicity on the molecules, and to introduce the potential for aromatic stacking interactions. In this paper we report spectroscopic data for fluorene, Fmoc and Fmoc conjugated to a small peptide (GRDS in this case) to enable interpretation of spectroscopic data collected on complex structures that can be created with Fmoc-peptide molecules. We report absorbance data (ultra violet and infrared), circular dichroism, linear dichroism (both film and Couette flow orientation) and Raman spectra. Orientations of the Fmoc chromophores in the linear dichroism studies are deduced.

Original languageEnglish
Pages (from-to)10854-10858
Number of pages5
JournalRSC Advances
Volume3
Issue number27
DOIs
Publication statusPublished - 2013
Externally publishedYes

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