SPET of a computerised model of diffuse lung disease

Peter Chicco, John S. Magnussen, Douglas W. Mackey, Vivienne Bush, Louise Emmett, Geoffrey Storey, George Bautovich, Hans Van Der Wall

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Emphysema is a common and debilitating disease that is the commonest cause of end-stage respiratory failure. Treatment is either by lung transplantation or by lung volume reduction surgery (LVRS) that improves the biomechanics of respiration. Patient selection for LVRS hinges on the demonstration of heterogeneous disease, predominantly involving the upper lobes, as a good surgical outcome is most likely in these patients. We used a virtual model of lung scintigraphy to compare planar with tomographic scintigraphy for the detection of diffuse lung disease. Lesions of the magnitude of the lung acinus, as well as larger and smaller lesions, were distributed throughout the lungs in volumes from 2% to 50%. Single-photon emission tomography does not add incremental value to planar images for the detection of diffuse lung disease.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Issue number2
Publication statusPublished - 2001
Externally publishedYes


  • Emphysema
  • Scintigraphy
  • Single-photon emission tomography


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