SPET of a computerised model of diffuse lung disease

Peter Chicco, John S. Magnussen, Douglas W. Mackey, Vivienne Bush, Louise Emmett, Geoffrey Storey, George Bautovich, Hans Van Der Wall

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Emphysema is a common and debilitating disease that is the commonest cause of end-stage respiratory failure. Treatment is either by lung transplantation or by lung volume reduction surgery (LVRS) that improves the biomechanics of respiration. Patient selection for LVRS hinges on the demonstration of heterogeneous disease, predominantly involving the upper lobes, as a good surgical outcome is most likely in these patients. We used a virtual model of lung scintigraphy to compare planar with tomographic scintigraphy for the detection of diffuse lung disease. Lesions of the magnitude of the lung acinus, as well as larger and smaller lesions, were distributed throughout the lungs in volumes from 2% to 50%. Single-photon emission tomography does not add incremental value to planar images for the detection of diffuse lung disease.

LanguageEnglish
Pages150-154
Number of pages5
JournalEuropean journal of nuclear medicine
Volume28
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Computer Simulation
Lung Diseases
Pneumonectomy
Radionuclide Imaging
Lung
Lung Transplantation
Emphysema
Photons
Biomechanical Phenomena
Respiratory Insufficiency
Patient Selection
Respiration
Tomography
Therapeutics

Keywords

  • Emphysema
  • Scintigraphy
  • Single-photon emission tomography

Cite this

Chicco, P., Magnussen, J. S., Mackey, D. W., Bush, V., Emmett, L., Storey, G., ... Van Der Wall, H. (2001). SPET of a computerised model of diffuse lung disease. European journal of nuclear medicine, 28(2), 150-154. https://doi.org/10.1007/s002590000425
Chicco, Peter ; Magnussen, John S. ; Mackey, Douglas W. ; Bush, Vivienne ; Emmett, Louise ; Storey, Geoffrey ; Bautovich, George ; Van Der Wall, Hans. / SPET of a computerised model of diffuse lung disease. In: European journal of nuclear medicine. 2001 ; Vol. 28, No. 2. pp. 150-154.
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Chicco, P, Magnussen, JS, Mackey, DW, Bush, V, Emmett, L, Storey, G, Bautovich, G & Van Der Wall, H 2001, 'SPET of a computerised model of diffuse lung disease', European journal of nuclear medicine, vol. 28, no. 2, pp. 150-154. https://doi.org/10.1007/s002590000425

SPET of a computerised model of diffuse lung disease. / Chicco, Peter; Magnussen, John S.; Mackey, Douglas W.; Bush, Vivienne; Emmett, Louise; Storey, Geoffrey; Bautovich, George; Van Der Wall, Hans.

In: European journal of nuclear medicine, Vol. 28, No. 2, 2001, p. 150-154.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - SPET of a computerised model of diffuse lung disease

AU - Chicco, Peter

AU - Magnussen, John S.

AU - Mackey, Douglas W.

AU - Bush, Vivienne

AU - Emmett, Louise

AU - Storey, Geoffrey

AU - Bautovich, George

AU - Van Der Wall, Hans

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AB - Emphysema is a common and debilitating disease that is the commonest cause of end-stage respiratory failure. Treatment is either by lung transplantation or by lung volume reduction surgery (LVRS) that improves the biomechanics of respiration. Patient selection for LVRS hinges on the demonstration of heterogeneous disease, predominantly involving the upper lobes, as a good surgical outcome is most likely in these patients. We used a virtual model of lung scintigraphy to compare planar with tomographic scintigraphy for the detection of diffuse lung disease. Lesions of the magnitude of the lung acinus, as well as larger and smaller lesions, were distributed throughout the lungs in volumes from 2% to 50%. Single-photon emission tomography does not add incremental value to planar images for the detection of diffuse lung disease.

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