Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives

Klaus Stolze*, Natascha Rohr-Udilova, Thomas Rosenau, Andreas Hofinger, Daniel Kolarich, Hans Nohl

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    In order to develop spin traps with an optimal ratio between hydrophilic and lipophilic properties, low toxicity, and high stability of spin adducts (especially with superoxide radicals), several EMPO-derived spin traps have recently been synthesized forming more stable superoxide adducts (t1/2 > 20 min) than DMPO or DEPMPO. In this study, ESR-, 1H-, and 13C-NMR data of several phenyl- or n-pentyl-substituted EMPO derivatives are presented with full signal assignment. Methyl groups at position 3 or 4 stabilized the superoxide adducts considerably. Spin adducts from other oxygen- and carbon-centered radicals (e.g., derived from methanol or linoleic acid hydroperoxide) are also described.

    Original languageEnglish
    Pages (from-to)3368-3376
    Number of pages9
    JournalBioorganic and Medicinal Chemistry
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 15 May 2006

    Keywords

    • EMPO derivatives
    • EPR
    • Spin trapping
    • Superoxide

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