Spinal cord serotonin release and raised blood pressure after braintem kainic acid injection

P. M. Pilowsky, V. Kapoor, J. B. Minson, M. J. West, J. P. Chalmers*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    71 Citations (Scopus)

    Abstract

    The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the B3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this release is associated with an increase in blood pressure.

    Original languageEnglish
    Pages (from-to)354-357
    Number of pages4
    JournalBrain Research
    Volume366
    Issue number1-2
    DOIs
    Publication statusPublished - 26 Feb 1986

    Keywords

    • bulbospinal serotonin neuron
    • in vivo brain dialysis
    • sympathetic activity
    • ventrolateral medulla

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