Spinal cord tissue affects ensheathing cell proliferation and apoptosis

Adele Woodhouse, Adele J. Vincent, Marie A. Kozel, Roger S. Chung, P. M E Waite, James C. Vickers, Adrian K. West, Meng Inn Chuah*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study investigates proliferation and apoptosis of olfactory ensheathing cells in cocultures with spinal cord tissue. Proliferation of ensheathing cells was significantly increased when cocultured with expiants from uninjured spinal cord, and spinal cord that had been subjected to chronic contusion or chronic needle stab injury, but not to acute needle stab injury. Proliferation rate was highest in cocultures with chronically stabbed cord tissue. Contaminating (p75NGFR-negative) cells in the cultures showed a significantly higher proliferation rate than ensheathing cells. Apoptosis of ensheathing cells was significantly increased in cocultures with acutely stabbed spinal cord expiants compared with chronically contused spinal cord expiants. These results suggest that delaying transplantation after spinal cord injury may be beneficial to ensheathing cell survival.

Original languageEnglish
Pages (from-to)737-740
Number of pages4
JournalNeuroReport
Volume16
Issue number7
DOIs
Publication statusPublished - 12 May 2005
Externally publishedYes

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