Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Angela M. Hong; Andrew E. Grulich; Deanna Jones; C. Soon Lee; Suzanne M. Garland; Timothy A. Dobbins; Jonathan R. Clark; Gerald B. Harnett; Christopher G. Milross; Christopher J. O'Brien; Barbara R. Rose

doi:10.1016/j.vaccine.2010.02.098

Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Angela M. Hong, Andrew E. Grulich, Deanna Jones, C. Soon Lee, Suzanne M. Garland, Timothy A. Dobbins, Jonathan R. Clark, Gerald B. Harnett, Christopher G. Milross, Christopher J. O'Brien, Barbara R. Rose^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987-1990) to 47% (2001-2005). HPV data used in conjunction with Australian cancer incidence data 2001-2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

Original language	English
Pages (from-to)	3269-3272
Number of pages	4
Journal	Vaccine
Volume	28
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2010.02.098
Publication status	Published - 26 Apr 2010
Externally published	Yes

Keywords

Human papillomavirus
Oropharyngeal cancer
p16

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10.1016/j.vaccine.2010.02.098

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title = "Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets",

abstract = "This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987-1990) to 47% (2001-2005). HPV data used in conjunction with Australian cancer incidence data 2001-2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.",

keywords = "Human papillomavirus, Oropharyngeal cancer, p16",

author = "Hong, {Angela M.} and Grulich, {Andrew E.} and Deanna Jones and Lee, {C. Soon} and Garland, {Suzanne M.} and Dobbins, {Timothy A.} and Clark, {Jonathan R.} and Harnett, {Gerald B.} and Milross, {Christopher G.} and O'Brien, {Christopher J.} and Rose, {Barbara R.}",

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AU - Grulich, Andrew E.

AU - Jones, Deanna

AU - Lee, C. Soon

AU - Garland, Suzanne M.

AU - Dobbins, Timothy A.

AU - Clark, Jonathan R.

AU - Harnett, Gerald B.

AU - Milross, Christopher G.

AU - O'Brien, Christopher J.

AU - Rose, Barbara R.

PY - 2010/4/26

Y1 - 2010/4/26

N2 - This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987-1990) to 47% (2001-2005). HPV data used in conjunction with Australian cancer incidence data 2001-2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

AB - This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987-1990) to 47% (2001-2005). HPV data used in conjunction with Australian cancer incidence data 2001-2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

KW - Human papillomavirus

KW - Oropharyngeal cancer

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JF - Vaccine

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ER -

Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Abstract

Keywords

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