Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Angela M. Hong, Andrew E. Grulich, Deanna Jones, C. Soon Lee, Suzanne M. Garland, Timothy A. Dobbins, Jonathan R. Clark, Gerald B. Harnett, Christopher G. Milross, Christopher J. O'Brien, Barbara R. Rose*

*Corresponding author for this work

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987-1990) to 47% (2001-2005). HPV data used in conjunction with Australian cancer incidence data 2001-2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

Original languageEnglish
Pages (from-to)3269-3272
Number of pages4
JournalVaccine
Volume28
Issue number19
DOIs
Publication statusPublished - 26 Apr 2010
Externally publishedYes

Keywords

  • Human papillomavirus
  • Oropharyngeal cancer
  • p16

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