Staging of patients after extrapleural pneumonectomy for malignant pleural mesothelioma - institutional review and current update

Christopher Cao, Sarah Karen Krog Andvik, Tristan D. Yan, Catherine Kennedy, Paul G. Bannon, Brian C. McCaughan

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Extrapleural pneumonectomy (EPP) has been established as a viable surgical option in the treatment of malignant pleural mesothelioma (MPM) for selected patients. A number of pathological staging systems have been developed to prognosticate survival outcomes. We assessed 91 patients with MPM who underwent EPP in our institution and evaluated the applicability of the most updated staging systems in the current literature. After a mean follow-up of 20 months, the median overall survival was 27.6 months. Postoperative pathological staging according to the International Mesothelioma Interest Group criteria (Ps0.026) and the Brigham and Women's Hospital criteria (Ps0.039) were both found to be significant prognostic factors. Adjuvant chemotherapy (Ps0.022) and radiotherapy (Ps0.008) were associated with improved survival outcomes. These findings are consistent with previous reports that demonstrated the usefulness of pathological staging systems as a prognostic tool in patients with MPM after undergoing EPP. However, preoperative clinical staging systems need to be developed to facilitate the patient selection process prior to surgery.

Original languageEnglish
Pages (from-to)754-757
Number of pages1
JournalInteractive Cardiovascular and Thoracic Surgery
Volume12
Issue number5
DOIs
Publication statusPublished - May 2011
Externally publishedYes

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