We report stamping surface-enhanced Raman spectroscopy (S-SERS) for label-free, multiplexed, molecular sensing and large-area, high-resolution molecular imaging on a flexible, nonplasmonic surface without solution-phase molecule transfer. In this technique, a polydimethylsiloxane (PDMS) thin film and nanoporous gold disk SERS substrate play the roles as molecule carrier and Raman signal enhancer, respectively. After stamping the SERS substrate onto the PDMS film, SERS measurements can be directly taken from the “sandwiched” target molecules. The performance of S-SERS is evaluated by the detection of Rhodamine 6G, urea, and its mixture with acetaminophen, in a physiologically relevant concentration range, along with the corresponding SERS spectroscopic maps. S-SERS features simple sample preparation, low cost, and high reproducibility, which could lead to SERS-based sensing and imaging for point-of-care and forensics applications.
Bibliographical noteCopyright the Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
- surface-enhanced Raman spectroscopy
- nanoporous gold disk
- polydimethylsiloxane stamping
- label-free molecular sensing and imaging
- solution-phase molecule transfer
Li, M., Lu, J., Qi, J., Zhao, F., Zeng, J., Yu, J. C-C., & Shih, W-C. (2014). Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging. Journal of Biomedical Optics, 19(5), 1-3. . https://doi.org/10.1117/1.JBO.19.5.050501