Standard virtual biological parts: A repository of modular modeling components for synthetic biology

M. T. Cooling*, V. Rouilly, G. Misirli, J. Lawson, T. Yu, J. Hallinan, A. Wipat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

Motivation: Fabrication of synthetic biological systems is greatly enhanced by incorporating engineering design principles and techniques such as computer-aided design. To this end, the ongoing standardization of biological parts presents an opportunity to develop libraries of standard virtual parts in the form of mathematical models that can be combined to inform system design. Results: We present an online Repository, populated with a collection of standardized models that can readily be recombined to model different biological systems using the inherent modularity support of the CellML 1.1 model exchange format. The applicability of this approach is demonstrated by modeling gold-medal winning iGEM machines. Availability and Implementation: The Repository is available online as part of http://models.cellml.org. We hope to stimulate the worldwide community to reuse and extend the models therein, and contribute to the Repository of Standard Virtual Parts thus founded. Systems Model architecture information for the Systems Model described here, along with an additional example and a tutorial, is also available as Supplementary information. The example Systems Model from this manuscript can be found at http://models.cellml.org/workspace/bugbuster. The Template models used in the example can be found at http://models.cellml.org/workspace/SVP_Templates200906. Contact: m.cooling@auckland.ac.nz. Supplementary information: Supplementary data are available at Bioinformatics online.

Original languageEnglish
Article numberbtq063
Pages (from-to)925-931
Number of pages7
JournalBioinformatics
Volume26
Issue number7
DOIs
Publication statusPublished - 16 Feb 2010
Externally publishedYes

Fingerprint

Dive into the research topics of 'Standard virtual biological parts: A repository of modular modeling components for synthetic biology'. Together they form a unique fingerprint.

Cite this