Statins in neuro-ophthalmology

Alvin Tan, Clare Fraser, Pauline Khoo, Stephanie Watson, Kenneth Ooi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Statins are effective and well-tolerated hypolipidaemic agents which have been increasingly studied for their pleiotropic immunomodulatory and anti-inflammatory effects. Statins have potential therapeutic benefit in a range of neuro-ophthalmological conditions but may also induce or exacerbate certain neurological disorders. This literature review examines evidence from clinical and in vitro studies assessing the effects of statins in myasthenia gravis, myopathy, multiple sclerosis, neuromyelitis optica, idiopathic intracranial hypertension (pseudotumour cerebri), migraine, giant cell arteritis, Bell’s palsy, ocular ischaemia, stroke, Alzheimer’s disease and Parkinson’s disease.

Original languageEnglish
Pages (from-to)219-237
Number of pages19
JournalNeuro-Ophthalmology
Volume45
Issue number4
Early online date24 Jun 2020
DOIs
Publication statusPublished - 4 Jul 2021
Externally publishedYes

Keywords

  • migraine
  • multiple sclerosis
  • Myasthenia gravis
  • myopathy
  • optic neuritis
  • stroke

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