Stereocontrolled synthesis of the cis-hydroxydecalin system: towards biologically active 19-nor-clerodanes

Paul Malek Mirzayans, Rebecca H. Pouwer, Craig M. Williams*, Paul V. Bernhardt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis-hydroxy decalin core in a concise fashion.

Original languageEnglish
Pages (from-to)1633-1638
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number8
Publication statusPublished - Mar 2012
Externally publishedYes


  • natural products
  • total synthesis
  • terpenoids
  • crotonin
  • spiro compounds
  • electrocyclization

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