Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

K. O. Tonga; G. G. King; C. S. Farah; C. Thamrin; F. S. Tang; J. Santos; P. Sharma; D. G. Chapman; B. G. Oliver

doi:10.1186/s12931-018-0880-2

Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

K. O. Tonga^*, G. G. King, C. S. Farah, C. Thamrin, F. S. Tang, J. Santos, P. Sharma, D. G. Chapman, B. G. Oliver

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

36 Downloads (Pure)

Abstract

There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.

Original language	English
Article number	176
Pages (from-to)	1-4
Number of pages	4
Journal	Respiratory Research
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12931-018-0880-2
Publication status	Published - 17 Sept 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Airway inflammation
Asthma
Fixed airflow obstruction
Reduced lung elastic recoil

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10.1186/s12931-018-0880-2

Publisher version (open access)Final published version, 748 KBLicence: CC BY

Cite this

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title = "Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma",

abstract = "There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.",

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AU - Tonga, K. O.

AU - King, G. G.

AU - Farah, C. S.

AU - Thamrin, C.

AU - Tang, F. S.

AU - Santos, J.

AU - Sharma, P.

AU - Chapman, D. G.

AU - Oliver, B. G.

N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2018/9/17

Y1 - 2018/9/17

N2 - There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.

AB - There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.

KW - Airway inflammation

KW - Asthma

KW - Fixed airflow obstruction

KW - Reduced lung elastic recoil

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ER -

Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

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