Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Ashour Sliow, Zhi Ma, Gaetano Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Rhiannon Kuchel, Giuseppe C. Tettamanzi, Richard D. Tilley, Samuel J. Frost, John Morley, Leonardo Longo, Antonio Lauto

Research output: Contribution to journalArticleResearchpeer-review

Abstract

An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

LanguageEnglish
Article number1801212
Pages1-13
Number of pages13
JournalAdvanced Science
Volume6
Issue number11
DOIs
Publication statusPublished - 5 Jun 2019

Fingerprint

nerves
stimulation
Peripheral Nerves
Grafts
Repair
antennas
Antennas
Transplants
Scaffolds
axons
Chitosan
Sciatic Nerve
muscles
regeneration
Adhesives
adhesives
Sutures
Action Potentials
rats
Axons

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • chitosan
  • lasers
  • nerve stimulators
  • photochemical tissue bonding
  • wireless antenna

Cite this

Sliow, A., Ma, Z., Gargiulo, G., Mahns, D., Mawad, D., Breen, P., ... Lauto, A. (2019). Stimulation and repair of peripheral nerves using bioadhesive graft-antenna. Advanced Science, 6(11), 1-13. [1801212]. https://doi.org/10.1002/advs.201801212
Sliow, Ashour ; Ma, Zhi ; Gargiulo, Gaetano ; Mahns, David ; Mawad, Damia ; Breen, Paul ; Stoodley, Marcus ; Houang, Jessica ; Kuchel, Rhiannon ; Tettamanzi, Giuseppe C. ; Tilley, Richard D. ; Frost, Samuel J. ; Morley, John ; Longo, Leonardo ; Lauto, Antonio. / Stimulation and repair of peripheral nerves using bioadhesive graft-antenna. In: Advanced Science. 2019 ; Vol. 6, No. 11. pp. 1-13.
@article{45ad8d8492c647438eeb5dc5680f2c8e,
title = "Stimulation and repair of peripheral nerves using bioadhesive graft-antenna",
abstract = "An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.",
keywords = "chitosan, lasers, nerve stimulators, photochemical tissue bonding, wireless antenna",
author = "Ashour Sliow and Zhi Ma and Gaetano Gargiulo and David Mahns and Damia Mawad and Paul Breen and Marcus Stoodley and Jessica Houang and Rhiannon Kuchel and Tettamanzi, {Giuseppe C.} and Tilley, {Richard D.} and Frost, {Samuel J.} and John Morley and Leonardo Longo and Antonio Lauto",
note = "Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
year = "2019",
month = "6",
day = "5",
doi = "10.1002/advs.201801212",
language = "English",
volume = "6",
pages = "1--13",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-Blackwell, Wiley",
number = "11",

}

Sliow, A, Ma, Z, Gargiulo, G, Mahns, D, Mawad, D, Breen, P, Stoodley, M, Houang, J, Kuchel, R, Tettamanzi, GC, Tilley, RD, Frost, SJ, Morley, J, Longo, L & Lauto, A 2019, 'Stimulation and repair of peripheral nerves using bioadhesive graft-antenna' Advanced Science, vol. 6, no. 11, 1801212, pp. 1-13. https://doi.org/10.1002/advs.201801212

Stimulation and repair of peripheral nerves using bioadhesive graft-antenna. / Sliow, Ashour; Ma, Zhi; Gargiulo, Gaetano; Mahns, David; Mawad, Damia; Breen, Paul; Stoodley, Marcus; Houang, Jessica; Kuchel, Rhiannon; Tettamanzi, Giuseppe C.; Tilley, Richard D.; Frost, Samuel J.; Morley, John; Longo, Leonardo; Lauto, Antonio.

In: Advanced Science, Vol. 6, No. 11, 1801212, 05.06.2019, p. 1-13.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

AU - Sliow,Ashour

AU - Ma,Zhi

AU - Gargiulo,Gaetano

AU - Mahns,David

AU - Mawad,Damia

AU - Breen,Paul

AU - Stoodley,Marcus

AU - Houang,Jessica

AU - Kuchel,Rhiannon

AU - Tettamanzi,Giuseppe C.

AU - Tilley,Richard D.

AU - Frost,Samuel J.

AU - Morley,John

AU - Longo,Leonardo

AU - Lauto,Antonio

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/6/5

Y1 - 2019/6/5

N2 - An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

AB - An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

KW - chitosan

KW - lasers

KW - nerve stimulators

KW - photochemical tissue bonding

KW - wireless antenna

UR - http://www.scopus.com/inward/record.url?scp=85063806225&partnerID=8YFLogxK

U2 - 10.1002/advs.201801212

DO - 10.1002/advs.201801212

M3 - Article

VL - 6

SP - 1

EP - 13

JO - Advanced Science

T2 - Advanced Science

JF - Advanced Science

SN - 2198-3844

IS - 11

M1 - 1801212

ER -

Sliow A, Ma Z, Gargiulo G, Mahns D, Mawad D, Breen P et al. Stimulation and repair of peripheral nerves using bioadhesive graft-antenna. Advanced Science. 2019 Jun 5;6(11):1-13. 1801212. https://doi.org/10.1002/advs.201801212