Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Ashour Sliow; Zhi Ma; Gaetano Gargiulo; David Mahns; Damia Mawad; Paul Breen; Marcus Stoodley; Jessica Houang; Rhiannon Kuchel; Giuseppe C. Tettamanzi; Richard D. Tilley; Samuel J. Frost; John Morley; Leonardo Longo; Antonio Lauto

doi:10.1002/advs.201801212

Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Ashour Sliow, Zhi Ma, Gaetano Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Rhiannon Kuchel, Giuseppe C. Tettamanzi, Richard D. Tilley, Samuel J. Frost, John Morley, Leonardo Longo, Antonio Lauto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

53 Downloads (Pure)

Abstract

An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

Original language	English
Article number	1801212
Pages (from-to)	1-13
Number of pages	13
Journal	Advanced Science
Volume	6
Issue number	11
DOIs	https://doi.org/10.1002/advs.201801212
Publication status	Published - 5 Jun 2019

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

chitosan
lasers
nerve stimulators
photochemical tissue bonding
wireless antenna

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10.1002/advs.201801212

Publisher version (open access)Final published version, 4.03 MBLicence: CC BY

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title = "Stimulation and repair of peripheral nerves using bioadhesive graft-antenna",

abstract = "An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.",

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AU - Ma, Zhi

AU - Gargiulo, Gaetano

AU - Mahns, David

AU - Mawad, Damia

AU - Breen, Paul

AU - Stoodley, Marcus

AU - Houang, Jessica

AU - Kuchel, Rhiannon

AU - Tettamanzi, Giuseppe C.

AU - Tilley, Richard D.

AU - Frost, Samuel J.

AU - Morley, John

AU - Longo, Leonardo

AU - Lauto, Antonio

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/6/5

Y1 - 2019/6/5

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AB - An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally-invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

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KW - nerve stimulators

KW - photochemical tissue bonding

KW - wireless antenna

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JO - Advanced Science

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ER -

Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

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