Stimulation of erythrocyte membrane Mg2+-ATPase activity by dinitrophenol and other membrane-disturbing agents

G. Bartosz*, M. Bartosz, A. Sokal, J. M. Gebicki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Erythrocyte membrane Mg2+-ATPase activity was stimulated by echinocytogenic agents (2,4-dinitrophenol and salicylate), a stomatocytogenic agent Triton X-100 and other membrane-disturbing agents including hydrophobic organic anions, alcohols and detergents. Various possible mechanisms of the stimulation are possible but apparently most probable one consists in induction of membrane phospholipid scrambling by the compounds studied (as demonstrated for DNP) and of aminophospholipid translocase (flippase) activity.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalBiochemistry and Molecular Biology International
Volume34
Issue number3
Publication statusPublished - 1994
Externally publishedYes

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