Stimuli-responsive prodrug-based cancer nanomedicine

Angel Xie, Sumaira Hanif, Jiang Ouyang, Zhongmin Tang, Na Kong, Na Yoon Kim, Baowen Qi, Dylan Patel, Bingyang Shi, Wei Tao

Research output: Contribution to journalReview article

Abstract

The rapid development of nanotechnology results in the emergence of nanomedicines, but the effective delivery of drugs to tumor sites remains a great challenge. Prodrug-based cancer nanomedicines thus emerged due to their unique advantages, including high drug load efficiency, reduced side effects, efficient targeting, and real-time controllability. A distinctive characteristic of prodrug-based nanomedicines is that they need to be activated by a stimulus or multi-stimulus to produce an anti-tumor effect. A better understanding of various responsive approaches could allow researchers to perceive the mechanism of prodrug-based nanomedicines effectively and further optimize their design strategy. In this review, we highlight the stimuli-responsive pathway of prodrug-based nanomedicines and their anticancer applications. Furthermore, various types of prodrug-based nanomedicines, recent progress and prospects of stimuli-responsive prodrug-based nanomedicines and patient data in the clinical application are also summarized. Additionally, the current development and future challenges of prodrug-based nanomedicines are discussed. We expect that this review will be valuable for readers to gain a deeper understanding of the structure and development of prodrug-based cancer nanomedicines to design rational and effective drugs for clinical use.
Original languageEnglish
Article number102821
Pages (from-to)1-12
Number of pages12
JournalEBioMedicine
Volume56
DOIs
Publication statusPublished - Jun 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Cancer therapy
  • Nanomedicine
  • Prodrug
  • Stimuli-responsive
  • Polymer

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  • Cite this

    Xie, A., Hanif, S., Ouyang, J., Tang, Z., Kong, N., Kim, N. Y., ... Tao, W. (2020). Stimuli-responsive prodrug-based cancer nanomedicine. EBioMedicine, 56, 1-12. [102821]. https://doi.org/10.1016/j.ebiom.2020.102821